Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
proCPyrroline-5-carboxylate reductase (NAD(P)-binding); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)    
Predicted Functional Partners:
PSHAa2604
Conserved protein of unknown function; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
 0.981
putA
Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
 0.975
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.936
PSHAb0543
Putative ornithine cyclodeaminase; Function of strongly homologous gene; enzyme.
   
 
 0.923
rdgB
Putative inosine/xanthosine triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.907
PSHAa2606
Putative integral membrane resistance protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter.
  
    0.894
proB-2
Glutamate-5 kinase(Gamma-glutamyl kinase)(GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.875
proB
Putative glutamate 5-kinase (Gamma-glutamyl kinase); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.856
PSHAa2607
Homologs of previously reported genes of unknown function.
       0.779
pilU
Twitching motility protein PilU (type IV pili); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
       0.753
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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