Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lexATranscriptional repressor for SOS response; Represses a number of genes involved in the response to DNA damage (SOS response). (182 aa)    
Predicted Functional Partners:
recA
RecA protein (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.982
dinB
DNA polymerase IV, devoid of proofreading, damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.781
umuC
Component of DNA polymerase V with UmuD; Function of strongly homologous gene; enzyme.
 
 
 0.756
recN
DNA repair protein recN; May be involved in recombinational repair of damaged DNA.
   
  
 0.711
PSHAa0834
Putative DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy.
   
  
 0.696
dgkA-2
Diacylglycerol kinase (DAGK) (Diglyceride kinase) (DGK); Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
      0.672
parE
DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.619
rplY
50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
     
 0.584
fadR
Fatty acid metabolism regulator protein; Multifunctional regulator of fatty acid metabolism.
      
 0.576
rstA
Response regulator (activator) in two-component regulatory; Function of strongly homologous gene; regulator.
      
 0.491
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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