| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa2630 | murA | PSHAa2630 | PSHAa2538 | Mannose-1-phosphate guanyltransferase-related protein; Function of strongly homologous gene; enzyme. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.826 |
| PSHAa2630 | murB | PSHAa2630 | PSHAa2914 | Mannose-1-phosphate guanyltransferase-related protein; Function of strongly homologous gene; enzyme. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.907 |
| birA | coaX | PSHAa2913 | PSHAa2912 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative transcriptional regulatory protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.977 |
| birA | murA | PSHAa2913 | PSHAa2538 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.487 |
| birA | murB | PSHAa2913 | PSHAa2914 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.964 |
| coaX | birA | PSHAa2912 | PSHAa2913 | Putative transcriptional regulatory protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.977 |
| coaX | murB | PSHAa2912 | PSHAa2914 | Putative transcriptional regulatory protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.871 |
| ddlB | murA | PSHAa2502 | PSHAa2538 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.821 |
| ddlB | murB | PSHAa2502 | PSHAa2914 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.813 |
| ddlB | murC | PSHAa2502 | PSHAa2503 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme; Cell wall formation; Belongs to the MurCDEF family. | 0.999 |
| ddlB | murD | PSHAa2502 | PSHAa2506 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.994 |
| ddlB | murE | PSHAa2502 | PSHAa2509 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | UDP-N-acetylmuramoylalanyl-D-glutamate 2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.957 |
| ddlB | murF | PSHAa2502 | PSHAa2508 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | D-alanine:D-alanine-adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |
| ddlB | murG | PSHAa2502 | PSHAa2504 | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.987 |
| murA | PSHAa2630 | PSHAa2538 | PSHAa2630 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | Mannose-1-phosphate guanyltransferase-related protein; Function of strongly homologous gene; enzyme. | 0.826 |
| murA | birA | PSHAa2538 | PSHAa2913 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.487 |
| murA | ddlB | PSHAa2538 | PSHAa2502 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | D-alanine-D-alanine ligase B, affects cell division; Cell wall formation. | 0.821 |
| murA | murB | PSHAa2538 | PSHAa2914 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.987 |
| murA | murC | PSHAa2538 | PSHAa2503 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme; Cell wall formation; Belongs to the MurCDEF family. | 0.979 |
| murA | murD | PSHAa2538 | PSHAa2506 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.883 |