Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa2946 | bdhA | PSHAa2946 | PSHAa2944 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Putative 3-hydroxybutyrate dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.869 |
| PSHAa2946 | metX | PSHAa2946 | PSHAa2945 | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Putative homoserine O-acetyltransferase (EC 2.3. 1.31); Function of strongly homologous gene; enzyme; Belongs to the AB hydrolase superfamily. MetX family. | 0.819 |
| PSHAb0477 | ilvA | PSHAb0477 | PSHAa2768 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.808 |
| PSHAb0477 | metA | PSHAb0477 | PSHAa2224 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Homoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.979 |
| PSHAb0477 | metB | PSHAb0477 | PSHAa2723 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Cystathionine gamma-synthase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.936 |
| PSHAb0477 | metL | PSHAb0477 | PSHAa2722 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Bifunctional: aspartokinase II (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.906 |
| PSHAb0477 | metX | PSHAb0477 | PSHAa2945 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative homoserine O-acetyltransferase (EC 2.3. 1.31); Function of strongly homologous gene; enzyme; Belongs to the AB hydrolase superfamily. MetX family. | 0.983 |
| PSHAb0477 | thrA | PSHAb0477 | PSHAa2379 | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Bifunctional aspartokinase/homoserine dehydrogenase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.906 |
| bdhA | PSHAa2946 | PSHAa2944 | PSHAa2946 | Putative 3-hydroxybutyrate dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | 0.869 |
| bdhA | metX | PSHAa2944 | PSHAa2945 | Putative 3-hydroxybutyrate dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative homoserine O-acetyltransferase (EC 2.3. 1.31); Function of strongly homologous gene; enzyme; Belongs to the AB hydrolase superfamily. MetX family. | 0.879 |
| glyA | ilvA | PSHAa2376 | PSHAa2768 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
| glyA | metA | PSHAa2376 | PSHAa2224 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| glyA | metL | PSHAa2376 | PSHAa2722 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional: aspartokinase II (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.499 |
| glyA | metX | PSHAa2376 | PSHAa2945 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative homoserine O-acetyltransferase (EC 2.3. 1.31); Function of strongly homologous gene; enzyme; Belongs to the AB hydrolase superfamily. MetX family. | 0.833 |
| glyA | serB | PSHAa2376 | PSHAa0661 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.935 |
| glyA | thrA | PSHAa2376 | PSHAa2379 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional aspartokinase/homoserine dehydrogenase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.703 |
| ilvA | PSHAb0477 | PSHAa2768 | PSHAb0477 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.808 |
| ilvA | glyA | PSHAa2768 | PSHAa2376 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
| ilvA | metA | PSHAa2768 | PSHAa2224 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.826 |
| ilvA | metB | PSHAa2768 | PSHAa2723 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Cystathionine gamma-synthase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.895 |
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