STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (643 aa)    
Predicted Functional Partners:
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.986
CVI81621.1
Thiamine-phosphate pyrophosphorylase.
 
 0.977
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.975
CVI83312.1
Phosphomethylpyrimidine kinase.
 
 
 0.975
CVI84920.1
Phosphomethylpyrimidine kinase type-1.
 
 
 0.971
CVI75208.1
Molybdopterin biosynthesis protein MoeB.
 
  
 0.926
thiM
Hydroxyethylthioazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
 
 0.914
CVI81625.1
Sulfur carrier protein ThiS.
  
  
 0.913
thiL
Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.768
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
    
 0.760
Your Current Organism:
Caballeronia humi
NCBI taxonomy Id: 326474
Other names: Burkholderia humi, Burkholderia humi Vandamme et al. 2013, Burkholderia sp. LMG 22934, Burkholderia sp. LMG 22935, Burkholderia sp. R-23322, Burkholderia sp. R-23323, Burkholderia sp. R-23328, Burkholderia sp. R-23370, C. humi, CCUG 63059, Caballeronia humi (Vandamme et al. 2013) Dobritsa and Samadpour 2016, LMG 22934, LMG:22934, Paraburkholderia humi, Paraburkholderia humi (Vandamme et al. 2013) Sawana et al. 2015, strain RA1-5
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