STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IscRFe-S cluster assembly transcriptional regulator IscR; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)    
Predicted Functional Partners:
iscS
IscS subfamily cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.978
NifU
Fe-S cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.936
hscB
Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
  
 0.842
IscA
Iron-sulfur cluster assembly protein IscA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family.
  
  
 0.694
fdx_1
Ferredoxin, 2Fe-2S type, ISC system; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.449
OSI11325.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
lldD
Alpha-hydroxy-acid oxidizing enzyme; Flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.417
aniA
Nitrite reductase, copper-containing; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the multicopper oxidase family.
  
  
 0.405
Your Current Organism:
Neisseria zoodegmatis
NCBI taxonomy Id: 326523
Other names: ATCC 29859, CDC D5986, DSM 21643, LMG 23012, LMG:23012, N. zoodegmatis, NCTC 12230, Neisseria sp. EF-4b, Neisseria sp. R-24681, Neisseria zoodegmatis Vandamme et al. 2006, strain CL 194/78
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