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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD7Mothers against decapentaplegic 7. (268 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase SMURF2.
    
 0.997
SMURF1
E3 ubiquitin-protein ligase SMURF1.
    
 0.997
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
   
 0.988
SMAD6
Mothers against decapentaplegic 6.
  
 
0.966
SMAD3
Mothers against decapentaplegic homolog.
   
0.964
SMAD2
Mothers against decapentaplegic homolog.
   
0.960
SMAD9
Mothers against decapentaplegic homolog.
    
0.959
SMAD1
Mothers against decapentaplegic homolog.
    
0.955
YAP1
Yorkie.
    
 0.928
WWTR1
WW domain-containing transcription regulator protein 1.
    
 0.928
Your Current Organism:
Manacus vitellinus
NCBI taxonomy Id: 328815
Other names: M. vitellinus, golden-collared manakin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.