A0A1Y2ALK8 protein (Rhizoclosmatium globosum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A1Y2ALK8

PKS_ER domain-containing protein. (796 aa)

Predicted Functional Partners:

A0A1Y2BYB8

0.773

A0A1Y2BS98

0.728

A0A1Y2CQ54

0.649

A0A1Y2BTP6

0.581

A0A1Y2BRR6

0.541

A0A1Y2C705

0.541

A0A1Y2CU24

0.541

A0A1Y2D0Z9

0.535

A0A1Y2B3L4

0.528

A0A1Y2CS65

0.515

Your Current Organism:

Rhizoclosmatium globosum

NCBI taxonomy Id: 329046
Other names: R. globosum, Rhizoclosmatium sp. JEL06

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2ALK8	A0A1Y2B3L4	PKS_ER domain-containing protein.	GroES-like protein.	0.528
A0A1Y2ALK8	A0A1Y2BRR6	PKS_ER domain-containing protein.	Phosphotransferase.	0.541
A0A1Y2ALK8	A0A1Y2BS98	PKS_ER domain-containing protein.	Short chain dehydrogenase.	0.728
A0A1Y2ALK8	A0A1Y2BTP6	PKS_ER domain-containing protein.	AAA-domain-containing protein; Belongs to the AAA ATPase family.	0.581
A0A1Y2ALK8	A0A1Y2BYB8	PKS_ER domain-containing protein.	Molybdopterin binding oxidoreductase.	0.773
A0A1Y2ALK8	A0A1Y2C705	PKS_ER domain-containing protein.	Phosphotransferase.	0.541
A0A1Y2ALK8	A0A1Y2CQ54	PKS_ER domain-containing protein.	Carrier domain-containing protein.	0.649
A0A1Y2ALK8	A0A1Y2CS65	PKS_ER domain-containing protein.	Mitochondrial hydroxyacid-oxoacid transhydrogenase.	0.515
A0A1Y2ALK8	A0A1Y2CU24	PKS_ER domain-containing protein.	Phosphotransferase.	0.541
A0A1Y2ALK8	A0A1Y2D0Z9	PKS_ER domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.535
A0A1Y2B3L4	A0A1Y2ALK8	GroES-like protein.	PKS_ER domain-containing protein.	0.528
A0A1Y2B3L4	A0A1Y2BRR6	GroES-like protein.	Phosphotransferase.	0.537
A0A1Y2B3L4	A0A1Y2BS98	GroES-like protein.	Short chain dehydrogenase.	0.728
A0A1Y2B3L4	A0A1Y2BTP6	GroES-like protein.	AAA-domain-containing protein; Belongs to the AAA ATPase family.	0.581
A0A1Y2B3L4	A0A1Y2BYB8	GroES-like protein.	Molybdopterin binding oxidoreductase.	0.773
A0A1Y2B3L4	A0A1Y2C705	GroES-like protein.	Phosphotransferase.	0.537
A0A1Y2B3L4	A0A1Y2CQ54	GroES-like protein.	Carrier domain-containing protein.	0.649
A0A1Y2B3L4	A0A1Y2CS65	GroES-like protein.	Mitochondrial hydroxyacid-oxoacid transhydrogenase.	0.515
A0A1Y2B3L4	A0A1Y2CU24	GroES-like protein.	Phosphotransferase.	0.537
A0A1Y2B3L4	A0A1Y2D0Z9	GroES-like protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.535

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.947

expected number of edges:

12

PPI enrichment p-value:

1.61e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006766

Vitamin metabolic process

5 of 31

2.18

2.95

1.08e-06

GO:0006767

Water-soluble vitamin metabolic process

4 of 19

2.3

2.45

1.90e-05

GO:0009235

Cobalamin metabolic process

3 of 6

2.68

2.13

0.00012

GO:0019751

Polyol metabolic process

4 of 46

1.92

1.8

0.00020

GO:0046174

Polyol catabolic process

3 of 14

2.31

1.71

0.00060

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016723

Oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

2 of 3

2.8

1.1

0.0104

GO:0016491

Oxidoreductase activity

7 of 474

1.15

1.09

0.00025

GO:0070402

NADPH binding

2 of 6

2.5

1.01

0.0146

GO:0031419

Cobalamin binding

2 of 5

2.58

1.01

0.0146

GO:0004029

Aldehyde dehydrogenase (NAD+) activity

2 of 6

2.5

1.01

0.0146

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12695

Cobalamin (Cbl) metabolism

4 of 6

2.8

3.52

3.06e-07

CL:12332

acetate-CoA ligase activity, and Aldehyde dehydrogenase (NAD+) activity

2 of 5

2.58

1.06

0.0115

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

2 of 15

2.1

1.09

0.0086

map00561

Glycerolipid metabolism

3 of 71

1.6

1.07

0.0052

map00053

Ascorbate and aldarate metabolism

2 of 18

2.02

1.07

0.0090

map00410

beta-Alanine metabolism

2 of 25

1.88

0.97

0.0133

map00790

Folate biosynthesis

2 of 32

1.77

0.89

0.0177

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9759218

Cobalamin (Cbl) metabolism

4 of 8

2.68

3.38

4.83e-07

MAP-196741

Cobalamin (Cbl, vitamin B12) transport and metabolism

4 of 15

2.4

3.06

1.26e-06

MAP-196849

Metabolism of water-soluble vitamins and cofactors

4 of 117

1.51

1.18

0.0020

MAP-196854

Metabolism of vitamins and cofactors

4 of 154

1.39

1.0

0.0045

MAP-156581

Methylation

2 of 10

2.28

1.0

0.0139

(more ...)

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