A0A1Y2BHF8 protein (Rhizoclosmatium globosum)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

A0A1Y2BHF8

MYND-type domain-containing protein. (400 aa)

Predicted Functional Partners:

A0A1Y2BD83

0.668

A0A1Y2BNN0

0.625

A0A1Y2BGG7

0.572

A0A1Y2BUC0

0.572

A0A1Y2CQC8

0.560

A0A1Y2D113

0.559

A0A1Y2BDV6

0.539

A0A1Y2CGN6

0.539

A0A1Y2BWU7

0.529

A0A1Y2BYK4

0.529

Your Current Organism:

Rhizoclosmatium globosum

NCBI taxonomy Id: 329046
Other names: R. globosum, Rhizoclosmatium sp. JEL06

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2BD83	A0A1Y2BDV6	POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-domain-containing protein.	0.790
A0A1Y2BD83	A0A1Y2BHF8	POZ domain-containing protein; Belongs to the SKP1 family.	MYND-type domain-containing protein.	0.668
A0A1Y2BD83	A0A1Y2BNN0	POZ domain-containing protein; Belongs to the SKP1 family.	Cullin-domain-containing protein; Belongs to the cullin family.	0.999
A0A1Y2BD83	A0A1Y2CGN6	POZ domain-containing protein; Belongs to the SKP1 family.	Ubiquitin-domain-containing protein.	0.828
A0A1Y2BD83	A0A1Y2CQC8	POZ domain-containing protein; Belongs to the SKP1 family.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.635
A0A1Y2BD83	A0A1Y2D113	POZ domain-containing protein; Belongs to the SKP1 family.	PCI-domain-containing protein.	0.701
A0A1Y2BDV6	A0A1Y2BD83	Ubiquitin-domain-containing protein.	POZ domain-containing protein; Belongs to the SKP1 family.	0.790
A0A1Y2BDV6	A0A1Y2BGG7	Ubiquitin-domain-containing protein.	Uncharacterized protein.	0.597
A0A1Y2BDV6	A0A1Y2BHF8	Ubiquitin-domain-containing protein.	MYND-type domain-containing protein.	0.539
A0A1Y2BDV6	A0A1Y2BNN0	Ubiquitin-domain-containing protein.	Cullin-domain-containing protein; Belongs to the cullin family.	0.756
A0A1Y2BDV6	A0A1Y2BUC0	Ubiquitin-domain-containing protein.	Uncharacterized protein.	0.597
A0A1Y2BDV6	A0A1Y2CQC8	Ubiquitin-domain-containing protein.	26S proteasome subunit P45; Belongs to the AAA ATPase family.	0.939
A0A1Y2BDV6	A0A1Y2D113	Ubiquitin-domain-containing protein.	PCI-domain-containing protein.	0.944
A0A1Y2BGG7	A0A1Y2BDV6	Uncharacterized protein.	Ubiquitin-domain-containing protein.	0.597
A0A1Y2BGG7	A0A1Y2BHF8	Uncharacterized protein.	MYND-type domain-containing protein.	0.572
A0A1Y2BGG7	A0A1Y2BNN0	Uncharacterized protein.	Cullin-domain-containing protein; Belongs to the cullin family.	0.605
A0A1Y2BGG7	A0A1Y2CGN6	Uncharacterized protein.	Ubiquitin-domain-containing protein.	0.597
A0A1Y2BHF8	A0A1Y2BD83	MYND-type domain-containing protein.	POZ domain-containing protein; Belongs to the SKP1 family.	0.668
A0A1Y2BHF8	A0A1Y2BDV6	MYND-type domain-containing protein.	Ubiquitin-domain-containing protein.	0.539
A0A1Y2BHF8	A0A1Y2BGG7	MYND-type domain-containing protein.	Uncharacterized protein.	0.572

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.896

expected number of edges:

14

PPI enrichment p-value:

0.0178

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060271

Cilium assembly

10 of 282

1.91

5.12

3.08e-15

GO:1905515

Non-motile cilium assembly

5 of 44

2.42

4.06

1.02e-08

GO:0007224

Smoothened signaling pathway

5 of 60

2.28

3.67

3.90e-08

GO:1904491

Protein localization to ciliary transition zone

3 of 6

3.06

3.0

3.47e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036038

MKS complex

10 of 11

3.32

14.87

1.59e-28

GO:0060170

Ciliary membrane

4 of 50

2.27

2.98

1.26e-06

GO:0036064

Ciliary basal body

3 of 134

1.71

1.19

0.0035

GO:0005813

Centrosome

4 of 433

1.33

1.0

0.0035

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23870701

(2013) Joubert syndrome: congenital cerebellar ataxia with the molar tooth.

6 of 25

2.74

5.34

7.18e-11

PMID:26673778

(2016) Large-scale targeted sequencing comparison highlights extreme genetic heterogeneity in nephronophthisis-related ciliopathies.

6 of 28

2.69

5.31

7.18e-11

PMID:25729630

(2014) Unraveling the genetics of Joubert and Meckel-Gruber syndromes.

6 of 30

2.66

5.28

7.18e-11

PMID:28401750

(2017) The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.

6 of 35

2.6

5.14

1.09e-10

PMID:23352055

(2012) The transition zone: an essential functional compartment of cilia.

6 of 37

2.57

5.1

1.19e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15866

Mixed, incl. Intraciliary transport particle, and Ciliary transition zone

11 of 76

2.52

10.72

2.14e-24

CL:15875

Mixed, incl. MKS complex, and Pronephros formation

8 of 20

2.97

9.88

1.29e-19

CL:15878

MKS complex, and Protein localization to ciliary transition zone

6 of 14

3.0

7.26

2.60e-14

CL:15880

MKS complex, and Predicted membrane protein

5 of 8

3.16

6.24

3.33e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-5620912

Anchoring of the basal body to the plasma membrane

4 of 83

2.05

2.07

6.69e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

11 of 14

3.26

16.39

9.85e-32

GOCC:0060170

Ciliary membrane

3 of 42

2.22

1.93

0.00019

GOCC:0036064

Ciliary basal body

2 of 53

1.94

0.74

0.0394

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0970

Cilium biogenesis/degradation

6 of 55

2.4

5.18

2.81e-11

KW-0969

Cilium

4 of 64

2.16

2.81

2.10e-06

KW-0966

Cell projection

5 of 160

1.86

2.63

1.01e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07162

Ciliary basal body-associated, B9 protein

3 of 3

3.36

3.07

2.90e-06

PF14995

Transmembrane protein

2 of 2

3.36

1.62

0.0012

PF09799

Predicted membrane protein

2 of 3

3.19

1.58

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010796

B9-type C2 domain

3 of 3

3.36

2.87

6.69e-06

IPR029248

Transmembrane protein 107

2 of 2

3.36

1.42

0.0028

IPR019184

Uncharacterised protein family, transmembrane-17

2 of 3

3.19

1.39

0.0031

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