B0A54_14033 protein (Friedmanniomyces endolithicus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

B0A54_14033

Uncharacterized protein. (521 aa)

Predicted Functional Partners:

B0A54_00498

0.900

B0A54_11537

0.900

B0A54_15457

0.875

B0A54_15613

0.875

B0A54_14853

0.836

B0A54_02220

0.676

B0A54_01329

0.667

B0A54_16121

0.614

B0A54_09334

0.614

B0A54_15069

0.613

Your Current Organism:

Friedmanniomyces endolithicus

NCBI taxonomy Id: 329885
Other names: CCFEE 5208, F. endolithicus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A54_00498	B0A54_01329	A0A4U0VH95	A0A4U0VK52	Uncharacterized protein.	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	0.510
B0A54_00498	B0A54_11537	A0A4U0VH95	A0A4V5N6X6	Uncharacterized protein.	Uncharacterized protein.	0.992
B0A54_00498	B0A54_14033	A0A4U0VH95	A0A4U0UGU6	Uncharacterized protein.	Uncharacterized protein.	0.900
B0A54_00498	B0A54_14853	A0A4U0VH95	A0A4U0UGZ2	Uncharacterized protein.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.871
B0A54_00498	B0A54_15069	A0A4U0VH95	A0A4U0U4C7	Uncharacterized protein.	Aminotran_1_2 domain-containing protein.	0.621
B0A54_00498	B0A54_15457	A0A4U0VH95	A0A4U0UB55	Uncharacterized protein.	Uncharacterized protein.	0.961
B0A54_00498	B0A54_15613	A0A4U0VH95	A0A4U0UBL5	Uncharacterized protein.	Uncharacterized protein.	0.961
B0A54_01329	B0A54_00498	A0A4U0VK52	A0A4U0VH95	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	Uncharacterized protein.	0.510
B0A54_01329	B0A54_02220	A0A4U0VK52	A0A4V5N969	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	Uncharacterized protein.	0.840
B0A54_01329	B0A54_11537	A0A4U0VK52	A0A4V5N6X6	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	Uncharacterized protein.	0.510
B0A54_01329	B0A54_14033	A0A4U0VK52	A0A4U0UGU6	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	Uncharacterized protein.	0.667
B0A54_01329	B0A54_14853	A0A4U0VK52	A0A4U0UGZ2	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.901
B0A54_02220	B0A54_01329	A0A4V5N969	A0A4U0VK52	Uncharacterized protein.	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	0.840
B0A54_02220	B0A54_09334	A0A4V5N969	A0A4U0UYP2	Uncharacterized protein.	Uncharacterized protein.	0.412
B0A54_02220	B0A54_14033	A0A4V5N969	A0A4U0UGU6	Uncharacterized protein.	Uncharacterized protein.	0.676
B0A54_02220	B0A54_14853	A0A4V5N969	A0A4U0UGZ2	Uncharacterized protein.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.927
B0A54_02220	B0A54_16121	A0A4V5N969	A0A4U0U1I6	Uncharacterized protein.	Uncharacterized protein.	0.412
B0A54_09334	B0A54_02220	A0A4U0UYP2	A0A4V5N969	Uncharacterized protein.	Uncharacterized protein.	0.412
B0A54_09334	B0A54_14033	A0A4U0UYP2	A0A4U0UGU6	Uncharacterized protein.	Uncharacterized protein.	0.614
B0A54_09334	B0A54_14853	A0A4U0UYP2	A0A4U0UGZ2	Uncharacterized protein.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.439

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.856

expected number of edges:

18

PPI enrichment p-value:

0.0139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032508

DNA duplex unwinding

4 of 51

2.01

1.8

0.00026

GO:0000723

Telomere maintenance

3 of 36

2.04

1.42

0.0018

GO:0070199

Establishment of protein localization to chromosome

2 of 6

2.64

1.35

0.0035

GO:0007004

Telomere maintenance via telomerase

2 of 5

2.72

1.35

0.0035

GO:2000573

Positive regulation of DNA biosynthetic process

2 of 9

2.47

1.25

0.0051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043047

Single-stranded telomeric DNA binding

2 of 4

2.82

1.21

0.0063

GO:0140097

Catalytic activity, acting on DNA

4 of 151

1.54

1.02

0.0063

GO:0009982

Pseudouridine synthase activity

2 of 10

2.42

1.01

0.0139

GO:0008094

ATP-dependent activity, acting on DNA

3 of 88

1.65

0.91

0.0139

GO:0004520

Endodeoxyribonuclease activity

2 of 21

2.1

0.88

0.0227

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

2 of 2

3.12

1.41

0.0029

GO:0005694

Chromosome

5 of 360

1.26

0.97

0.0029

GO:0005657

Replication fork

2 of 27

1.99

0.82

0.0280

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 1612

0.76

0.5

0.0145

GO:0070013

Intracellular organelle lumen

5 of 993

0.82

0.46

0.0427

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5386

Homologous DNA Pairing and Strand Exchange, and Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

3 of 20

2.3

1.89

0.00026

CL:5382

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and DNA polymerase complex

4 of 60

1.94

1.81

0.00021

CL:5399

Sensing of DNA Double Strand Breaks, and D-loop DNA binding

2 of 5

2.72

1.48

0.0020

CL:7848

Box H/ACA RNP complex, and Box H/ACA snoRNP assembly

2 of 6

2.64

1.42

0.0025

CL:4172

Protein palmitoylation, and Telomere assembly

2 of 11

2.38

1.19

0.0063

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03450

Non-homologous end-joining

2 of 12

2.34

1.16

0.0072

map03440

Homologous recombination

2 of 54

1.69

0.67

0.0496

map03030

DNA replication

2 of 49

1.73

0.67

0.0496

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685938

HDR through Single Strand Annealing (SSA)

4 of 26

2.31

2.7

5.73e-06

MAP-180786

Extension of Telomeres

4 of 28

2.28

2.68

5.73e-06

MAP-157579

Telomere Maintenance

4 of 35

2.18

2.63

5.73e-06

MAP-5693607

Processing of DNA double-strand break ends

4 of 36

2.17

2.62

5.73e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 39

2.13

2.6

5.73e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

2 of 5

2.72

1.09

0.0106

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