PAN3 protein (Friedmanniomyces endolithicus)

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Predicted Interactions

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PAN3

PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (707 aa)

Predicted Functional Partners:

PAN2

0.998

B0A54_01115

0.998

B0A54_11714

0.970

B0A54_11716

0.970

B0A54_07907

0.970

B0A54_17113

0.931

B0A54_07527

0.931

B0A54_12582

0.892

B0A54_12288

0.892

B0A54_10931

0.892

Your Current Organism:

Friedmanniomyces endolithicus

NCBI taxonomy Id: 329885
Other names: CCFEE 5208, F. endolithicus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A54_01115	B0A54_07527	A0A4V5N9V4	A0A4U0V2B4	USP domain-containing protein.	Glyco_hydro_32C domain-containing protein.	0.916
B0A54_01115	B0A54_07907	A0A4V5N9V4	A0A4U0UXX5	USP domain-containing protein.	Uncharacterized protein.	0.967
B0A54_01115	B0A54_11714	A0A4V5N9V4	A0A4U0UPA8	USP domain-containing protein.	Uncharacterized protein.	0.967
B0A54_01115	B0A54_11716	A0A4V5N9V4	A0A4U0UQP4	USP domain-containing protein.	Uncharacterized protein.	0.967
B0A54_01115	B0A54_17113	A0A4V5N9V4	A0A4U0TTV1	USP domain-containing protein.	Uncharacterized protein.	0.916
B0A54_01115	PAN3	A0A4V5N9V4	A0A4U0UH19	USP domain-containing protein.	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...]	0.998
B0A54_07527	B0A54_01115	A0A4U0V2B4	A0A4V5N9V4	Glyco_hydro_32C domain-containing protein.	USP domain-containing protein.	0.916
B0A54_07527	B0A54_10931	A0A4U0V2B4	A0A4U0UQN1	Glyco_hydro_32C domain-containing protein.	Exonuclease domain-containing protein.	0.686
B0A54_07527	B0A54_12288	A0A4U0V2B4	A0A4U0UJH8	Glyco_hydro_32C domain-containing protein.	Exonuclease domain-containing protein.	0.686
B0A54_07527	B0A54_12582	A0A4U0V2B4	A0A4U0UJ56	Glyco_hydro_32C domain-containing protein.	Exonuclease domain-containing protein.	0.686
B0A54_07527	PAN2	A0A4U0V2B4	A0A4U0TTC3	Glyco_hydro_32C domain-containing protein.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]	0.916
B0A54_07527	PAN3	A0A4U0V2B4	A0A4U0UH19	Glyco_hydro_32C domain-containing protein.	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...]	0.931
B0A54_07907	B0A54_01115	A0A4U0UXX5	A0A4V5N9V4	Uncharacterized protein.	USP domain-containing protein.	0.967
B0A54_07907	B0A54_10931	A0A4U0UXX5	A0A4U0UQN1	Uncharacterized protein.	Exonuclease domain-containing protein.	0.686
B0A54_07907	B0A54_12288	A0A4U0UXX5	A0A4U0UJH8	Uncharacterized protein.	Exonuclease domain-containing protein.	0.686
B0A54_07907	B0A54_12582	A0A4U0UXX5	A0A4U0UJ56	Uncharacterized protein.	Exonuclease domain-containing protein.	0.686
B0A54_07907	PAN2	A0A4U0UXX5	A0A4U0TTC3	Uncharacterized protein.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]	0.967
B0A54_07907	PAN3	A0A4U0UXX5	A0A4U0UH19	Uncharacterized protein.	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...]	0.970
B0A54_10931	B0A54_07527	A0A4U0UQN1	A0A4U0V2B4	Exonuclease domain-containing protein.	Glyco_hydro_32C domain-containing protein.	0.686
B0A54_10931	B0A54_07907	A0A4U0UQN1	A0A4U0UXX5	Exonuclease domain-containing protein.	Uncharacterized protein.	0.686

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Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.631

expected number of edges:

21

PPI enrichment p-value:

0.00195

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019439

Aromatic compound catabolic process

8 of 44

1.63

2.89

2.49e-09

GO:0009056

Catabolic process

9 of 136

1.19

1.57

1.11e-07

GO:0044270

Cellular nitrogen compound catabolic process

3 of 29

1.38

0.75

0.0230

GO:0046700

Heterocycle catabolic process

3 of 32

1.34

0.7

0.0278

GO:0044281

Small molecule metabolic process

11 of 523

0.69

0.65

6.89e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051537

2 iron, 2 sulfur cluster binding

4 of 9

2.02

2.05

7.01e-05

GO:0071949

FAD binding

3 of 6

2.07

1.57

0.00089

GO:0016491

Oxidoreductase activity

8 of 247

0.88

0.78

0.00029

GO:0043167

Ion binding

9 of 681

0.49

0.33

0.0247

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2554

Aromatic compound catabolic process

8 of 16

2.07

4.97

1.35e-12

CL:2556

CO dehydrogenase flavoprotein, C-terminal, and Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

6 of 7

2.3

4.57

3.52e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

4 of 90

1.02

0.59

0.0257

map01120

Microbial metabolism in diverse environments

6 of 236

0.78

0.48

0.0225

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01799

[2Fe-2S] binding domain

3 of 3

2.37

1.77

0.00047

PF00941

FAD binding domain in molybdopterin dehydrogenase

3 of 3

2.37

1.77

0.00047

PF00111

2Fe-2S iron-sulfur cluster binding domain

3 of 5

2.15

1.72

0.00047

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036683

CO dehydrogenase flavoprotein, C-terminal domain superfamily

4 of 4

2.37

2.53

1.44e-05

IPR005107

CO dehydrogenase flavoprotein, C-terminal

4 of 4

2.37

2.53

1.44e-05

IPR036884

[2Fe-2S]-binding domain superfamily

3 of 3

2.37

1.79

0.00044

IPR002888

[2Fe-2S]-binding

3 of 3

2.37

1.79

0.00044

IPR002346

Molybdopterin dehydrogenase, FAD-binding

3 of 3

2.37

1.79

0.00044

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01092

CO dehydrogenase flavoprotein C-terminal domain

3 of 3

2.37

2.07

0.00012

SM01008

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

2 of 5

1.97

0.92

0.0177

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