B0A54_09699 protein (Friedmanniomyces endolithicus)

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Known Interactions

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Predicted Interactions

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Score

B0A54_09699

Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (241 aa)

Predicted Functional Partners:

B0A54_04464

0.738

B0A54_03874

0.738

B0A54_17558

0.699

B0A54_05018

0.699

B0A54_09218

0.544

B0A54_09468

0.544

B0A54_01671

0.544

B0A54_02482

0.544

B0A54_04471

0.528

B0A54_03884

0.528

Your Current Organism:

Friedmanniomyces endolithicus

NCBI taxonomy Id: 329885
Other names: CCFEE 5208, F. endolithicus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A54_01671	B0A54_05018	A0A4U0VGI4	A0A4U0V8R4	Lactamase_B domain-containing protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.803
B0A54_01671	B0A54_09699	A0A4U0VGI4	A0A4U0UU56	Lactamase_B domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.544
B0A54_01671	B0A54_17558	A0A4U0VGI4	A0A4U0TPL1	Lactamase_B domain-containing protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.803
B0A54_02482	B0A54_05018	A0A4V5N9H0	A0A4U0V8R4	Adrenodoxin mitochondrial.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.803
B0A54_02482	B0A54_09699	A0A4V5N9H0	A0A4U0UU56	Adrenodoxin mitochondrial.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.544
B0A54_02482	B0A54_17558	A0A4V5N9H0	A0A4U0TPL1	Adrenodoxin mitochondrial.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.803
B0A54_03874	B0A54_04464	A0A4U0VD54	A0A4U0V911	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.843
B0A54_03874	B0A54_09699	A0A4U0VD54	A0A4U0UU56	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.738
B0A54_03884	B0A54_05018	A0A4U0VD64	A0A4U0V8R4	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.470
B0A54_03884	B0A54_09699	A0A4U0VD64	A0A4U0UU56	Uncharacterized protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.528
B0A54_03884	B0A54_17558	A0A4U0VD64	A0A4U0TPL1	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.470
B0A54_04464	B0A54_03874	A0A4U0V911	A0A4U0VD54	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.843
B0A54_04464	B0A54_09699	A0A4U0V911	A0A4U0UU56	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.738
B0A54_04471	B0A54_05018	A0A4U0VBJ6	A0A4U0V8R4	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.470
B0A54_04471	B0A54_09699	A0A4U0VBJ6	A0A4U0UU56	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.528
B0A54_04471	B0A54_17558	A0A4U0VBJ6	A0A4U0TPL1	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.470
B0A54_05018	B0A54_01671	A0A4U0V8R4	A0A4U0VGI4	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Lactamase_B domain-containing protein.	0.803
B0A54_05018	B0A54_02482	A0A4U0V8R4	A0A4V5N9H0	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Adrenodoxin mitochondrial.	0.803
B0A54_05018	B0A54_03884	A0A4U0V8R4	A0A4U0VD64	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Uncharacterized protein.	0.470
B0A54_05018	B0A54_04471	A0A4U0V8R4	A0A4U0VBJ6	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.470

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003756

Protein disulfide isomerase activity

4 of 4

3.32

4.69

3.06e-09

GO:0015035

Protein-disulfide reductase activity

4 of 19

2.64

3.66

1.29e-07

GO:0140096

Catalytic activity, acting on a protein

7 of 1397

1.02

0.97

0.00016

GO:0003824

Catalytic activity

9 of 5325

0.55

0.39

0.0114

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005788

Endoplasmic reticulum lumen

2 of 22

2.28

0.89

0.0232

GO:0005737

Cytoplasm

10 of 5892

0.55

0.4

0.0084

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29562928

(2018) Trees, fungi and bacteria: tripartite metatranscriptomics of a root microbiome responding to soil contamination.

2 of 15

2.45

1.74

0.00059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11481

Thioredoxin domain, and Peroxiredoxin-5-like

4 of 11

2.88

3.81

9.09e-08

CL:11484

Protein repair, and Peroxiredoxin-5-like

3 of 6

3.02

2.89

5.37e-06

CL:11272

Mixed, incl. Protein disulfide isomerase activity, and Protein folding in endoplasmic reticulum

3 of 11

2.76

2.59

1.74e-05

CL:23485

Ammonia transport, and Permease family

2 of 5

2.92

1.56

0.0015

CL:11059

Protein folding, and Conjugation with cellular fusion

4 of 188

1.65

1.46

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

7 of 268

1.74

3.22

1.50e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3299685

Detoxification of Reactive Oxygen Species

3 of 28

2.35

1.84

0.00034

MAP-5676934

Protein repair

2 of 4

3.02

1.56

0.0015

MAP-844456

The NLRP3 inflammasome

2 of 11

2.58

1.32

0.0038

MAP-622312

Inflammasomes

2 of 11

2.58

1.32

0.0038

MAP-9711123

Cellular response to chemical stress

3 of 86

1.86

1.28

0.0028

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

4 of 298

1.45

1.03

0.0045

GOCC:0005737

Cytoplasm

9 of 3800

0.7

0.52

0.0037

GOCC:0005622

Intracellular

11 of 8487

0.43

0.34

0.0058

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

5 of 9

3.07

6.16

4.11e-12

KW-1015

Disulfide bond

5 of 62

2.23

3.87

9.81e-09

KW-0413

Isomerase

3 of 55

2.06

1.87

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00085

Thioredoxin

6 of 7

3.25

7.81

4.34e-15

PF14595

Thioredoxin

2 of 2

3.32

1.75

0.00071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013766

Thioredoxin domain

8 of 17

2.99

9.74

2.91e-19

IPR036249

Thioredoxin-like superfamily

9 of 81

2.37

7.62

1.23e-17

IPR017937

Thioredoxin, conserved site

5 of 6

3.24

6.22

4.21e-12

IPR005788

Disulphide isomerase

2 of 2

3.32

1.67

0.00099

IPR005746

Thioredoxin

2 of 2

3.32

1.67

0.00099

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