B0A54_05267 protein (Friedmanniomyces endolithicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B0A54_05267

Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (612 aa)

Predicted Functional Partners:

CIA1

0.995

CIA1-2

0.995

B0A54_01589

0.924

B0A54_16689

0.924

B0A54_16882

0.831

B0A54_11856

0.831

B0A54_09218

0.824

B0A54_02482

0.824

B0A54_09468

0.806

B0A54_01671

0.806

Your Current Organism:

Friedmanniomyces endolithicus

NCBI taxonomy Id: 329885
Other names: CCFEE 5208, F. endolithicus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A54_01589	B0A54_05267	A0A4U0VFZ1	A0A4U0V6Q1	FeS_assembly_P domain-containing protein.	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	0.924
B0A54_01589	B0A54_11856	A0A4U0VFZ1	A0A4U0ULP1	FeS_assembly_P domain-containing protein.	Uncharacterized protein.	0.988
B0A54_01589	B0A54_16882	A0A4U0VFZ1	A0A4U0U3J3	FeS_assembly_P domain-containing protein.	Uncharacterized protein.	0.988
B0A54_01589	CIA1	A0A4U0VFZ1	A0A4U0V1U1	FeS_assembly_P domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.999
B0A54_01589	CIA1-2	A0A4U0VFZ1	A0A4U0VIQ3	FeS_assembly_P domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.999
B0A54_01671	B0A54_05267	A0A4U0VGI4	A0A4U0V6Q1	Lactamase_B domain-containing protein.	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	0.806
B0A54_01671	CIA1	A0A4U0VGI4	A0A4U0V1U1	Lactamase_B domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.506
B0A54_01671	CIA1-2	A0A4U0VGI4	A0A4U0VIQ3	Lactamase_B domain-containing protein.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.506
B0A54_02482	B0A54_05267	A0A4V5N9H0	A0A4U0V6Q1	Adrenodoxin mitochondrial.	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	0.824
B0A54_02482	CIA1	A0A4V5N9H0	A0A4U0V1U1	Adrenodoxin mitochondrial.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.506
B0A54_02482	CIA1-2	A0A4V5N9H0	A0A4U0VIQ3	Adrenodoxin mitochondrial.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.506
B0A54_05267	B0A54_01589	A0A4U0V6Q1	A0A4U0VFZ1	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	FeS_assembly_P domain-containing protein.	0.924
B0A54_05267	B0A54_01671	A0A4U0V6Q1	A0A4U0VGI4	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Lactamase_B domain-containing protein.	0.806
B0A54_05267	B0A54_02482	A0A4U0V6Q1	A0A4V5N9H0	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Adrenodoxin mitochondrial.	0.824
B0A54_05267	B0A54_09218	A0A4U0V6Q1	A0A4U0UQN7	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	2Fe-2S ferredoxin-type domain-containing protein.	0.824
B0A54_05267	B0A54_09468	A0A4U0V6Q1	A0A4U0US04	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Lactamase_B domain-containing protein.	0.806
B0A54_05267	B0A54_11856	A0A4U0V6Q1	A0A4U0ULP1	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Uncharacterized protein.	0.831
B0A54_05267	B0A54_16689	A0A4U0V6Q1	A0A4V5N4D3	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	FeS_assembly_P domain-containing protein.	0.924
B0A54_05267	B0A54_16882	A0A4U0V6Q1	A0A4U0U3J3	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Uncharacterized protein.	0.831
B0A54_05267	CIA1	A0A4U0V6Q1	A0A4U0V1U1	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.995

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.701

expected number of edges:

10

PPI enrichment p-value:

7.98e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

11 of 24

2.26

8.41

1.92e-21

GO:0050896

Response to stimulus

11 of 334

1.11

1.61

2.89e-11

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

11 of 24

2.26

8.48

1.09e-21

GO:0003677

DNA binding

11 of 369

1.07

1.45

3.36e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1196

0.56

0.49

8.24e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6080

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

10 of 35

2.05

6.17

5.00e-17

CL:6082

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

8 of 28

2.05

5.1

3.69e-13

CL:6084

RNA polymerase sigma-70 like, and FecR protein

7 of 22

2.1

4.7

1.65e-11

CL:6109

Sigma-70, region 4

4 of 6

2.42

3.18

7.33e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 478

0.96

1.16

4.17e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

11 of 55

1.9

5.74

1.17e-18

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

11 of 22

2.3

8.94

1.53e-22

KW-0238

DNA-binding

11 of 178

1.39

2.67

4.04e-14

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04542

Sigma-70 region 2

10 of 19

2.32

8.05

2.09e-19

PF08281

Sigma-70, region 4

8 of 13

2.39

6.76

3.32e-15

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007627

RNA polymerase sigma-70 region 2

11 of 20

2.34

9.0

4.97e-22

IPR039425

RNA polymerase sigma-70 like

11 of 21

2.32

8.89

4.97e-22

IPR014284

RNA polymerase sigma-70 like domain

11 of 22

2.3

8.78

4.97e-22

IPR013325

RNA polymerase sigma factor, region 2

11 of 22

2.3

8.78

4.97e-22

IPR013324

RNA polymerase sigma factor, region 3/4-like

11 of 22

2.3

8.78

4.97e-22

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About