B0A54_00681 protein (Friedmanniomyces endolithicus)

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

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B0A54_00681

TFIIS central domain-containing protein. (829 aa)

Predicted Functional Partners:

B0A54_08074

0.954

B0A54_15549

0.892

B0A54_08647

0.892

B0A54_06452

0.892

B0A54_02838

0.892

B0A54_03667

0.892

B0A54_12284

0.892

B0A54_16724

0.851

B0A54_14170

0.851

B0A54_00691

0.849

Your Current Organism:

Friedmanniomyces endolithicus

NCBI taxonomy Id: 329885
Other names: CCFEE 5208, F. endolithicus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A54_00681	B0A54_00691	A0A4U0VJM9	A0A4U0VJN7	TFIIS central domain-containing protein.	HECT domain-containing protein.	0.849
B0A54_00681	B0A54_02838	A0A4U0VJM9	A0A4U0VBR8	TFIIS central domain-containing protein.	Uncharacterized protein.	0.892
B0A54_00681	B0A54_03667	A0A4U0VJM9	A0A4U0VCJ8	TFIIS central domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.892
B0A54_00681	B0A54_06452	A0A4U0VJM9	A0A4U0UZE7	TFIIS central domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.892
B0A54_00681	B0A54_08074	A0A4U0VJM9	A0A4U0UXF4	TFIIS central domain-containing protein.	Uncharacterized protein.	0.954
B0A54_00681	B0A54_08647	A0A4U0VJM9	A0A4U0UUD2	TFIIS central domain-containing protein.	Sister chromatid cohesion protein.	0.892
B0A54_00681	B0A54_12284	A0A4U0VJM9	A0A4V5N6G7	TFIIS central domain-containing protein.	Sister chromatid cohesion protein.	0.892
B0A54_00681	B0A54_14170	A0A4U0VJM9	A0A4U0UGI5	TFIIS central domain-containing protein.	RPOLD domain-containing protein.	0.851
B0A54_00681	B0A54_15549	A0A4U0VJM9	A0A4U0U711	TFIIS central domain-containing protein.	Uncharacterized protein.	0.892
B0A54_00681	B0A54_16724	A0A4U0VJM9	A0A4U0TYM9	TFIIS central domain-containing protein.	RPOLD domain-containing protein.	0.851
B0A54_00691	B0A54_00681	A0A4U0VJN7	A0A4U0VJM9	HECT domain-containing protein.	TFIIS central domain-containing protein.	0.849
B0A54_00691	B0A54_08647	A0A4U0VJN7	A0A4U0UUD2	HECT domain-containing protein.	Sister chromatid cohesion protein.	0.446
B0A54_00691	B0A54_12284	A0A4U0VJN7	A0A4V5N6G7	HECT domain-containing protein.	Sister chromatid cohesion protein.	0.446
B0A54_02838	B0A54_00681	A0A4U0VBR8	A0A4U0VJM9	Uncharacterized protein.	TFIIS central domain-containing protein.	0.892
B0A54_02838	B0A54_08074	A0A4U0VBR8	A0A4U0UXF4	Uncharacterized protein.	Uncharacterized protein.	0.997
B0A54_02838	B0A54_14170	A0A4U0VBR8	A0A4U0UGI5	Uncharacterized protein.	RPOLD domain-containing protein.	0.974
B0A54_02838	B0A54_16724	A0A4U0VBR8	A0A4U0TYM9	Uncharacterized protein.	RPOLD domain-containing protein.	0.974
B0A54_03667	B0A54_00681	A0A4U0VCJ8	A0A4U0VJM9	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	TFIIS central domain-containing protein.	0.892
B0A54_03667	B0A54_08074	A0A4U0VCJ8	A0A4U0UXF4	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Uncharacterized protein.	0.997
B0A54_03667	B0A54_14170	A0A4U0VCJ8	A0A4U0UGI5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	RPOLD domain-containing protein.	0.974

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.867

expected number of edges:

10

PPI enrichment p-value:

0.0092

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

6 of 23

2.57

5.31

4.10e-11

GO:0042180

Cellular ketone metabolic process

7 of 71

2.14

4.66

4.10e-11

GO:0044283

Small molecule biosynthetic process

9 of 458

1.44

2.47

5.09e-10

GO:0032259

Methylation

6 of 183

1.67

2.41

6.03e-07

GO:0006568

Tryptophan metabolic process

3 of 13

2.51

2.34

4.14e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004395

Hexaprenyldihydroxybenzoate methyltransferase activity

6 of 6

3.15

7.26

3.93e-14

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

5 of 5

3.15

6.0

9.23e-12

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

5 of 7

3.0

5.8

1.74e-11

GO:0004834

Tryptophan synthase activity

2 of 3

2.97

1.75

0.00068

GO:0016740

Transferase activity

7 of 1615

0.79

0.59

0.0039

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031314

Extrinsic component of mitochondrial inner membrane

5 of 22

2.51

4.31

4.12e-09

GO:0019898

Extrinsic component of membrane

6 of 97

1.94

3.39

1.38e-08

GO:0005743

Mitochondrial inner membrane

6 of 358

1.37

1.62

1.39e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15336

Ubiquinol biosynthesis, and ABC1 atypical kinase-like domain

6 of 26

2.51

5.34

2.57e-11

CL:15180

Mixed, incl. Tryptophan catabolism, and Ubiquinol biosynthesis

8 of 104

2.04

4.81

2.22e-12

CL:15339

Ubiquinone metabolic process, and ABC1 atypical kinase-like domain

5 of 20

2.55

4.44

2.60e-09

CL:15342

Ubiquinone biosynthesis, and ABC1 atypical kinase-like domain

4 of 15

2.58

3.43

3.16e-07

CL:13512

Tryptophan biosynthetic process

2 of 5

2.75

1.29

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

7 of 59

2.22

5.44

8.78e-13

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

2 of 25

2.05

1.17

0.0059

map01110

Biosynthesis of secondary metabolites

6 of 1057

0.9

0.72

0.0017

map01100

Metabolic pathways

11 of 3257

0.68

0.64

2.65e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2142789

Ubiquinol biosynthesis

8 of 22

2.71

8.54

1.10e-17

MAP-8978934

Metabolism of cofactors

8 of 40

2.45

7.31

3.54e-16

MAP-196854

Metabolism of vitamins and cofactors

8 of 220

1.71

3.41

9.71e-11

MAP-1430728

Metabolism

9 of 2234

0.75

0.65

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

7 of 971

1.01

0.85

0.0011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 140

1.7

2.14

7.82e-06

KW-0822

Tryptophan biosynthesis

2 of 3

2.97

1.77

0.00061

KW-0663

Pyridoxal phosphate

3 of 58

1.86

1.51

0.00083

KW-0831

Ubiquinone biosynthesis

2 of 9

2.5

1.5

0.0017

KW-0999

Mitochondrion inner membrane

2 of 57

1.69

0.78

0.0291

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00290

Tryptophan synthase alpha chain

2 of 2

3.15

1.31

0.0044

PF13847

Methyltransferase domain

2 of 11

2.41

0.85

0.0282

PF00291

Pyridoxal-phosphate dependent enzyme

2 of 14

2.3

0.84

0.0289

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

5 of 167

1.63

1.53

0.00032

IPR023026

Tryptophan synthase beta chain/beta chain-like

2 of 3

2.97

1.22

0.0063

IPR018204

Tryptophan synthase, alpha chain, active site

2 of 2

3.15

1.22

0.0063

IPR006654

Tryptophan synthase, beta chain

2 of 3

2.97

1.22

0.0063

IPR006653

Tryptophan synthase, beta chain, conserved site

2 of 3

2.97

1.22

0.0063

(more ...)

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