| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ72465.1 | KWZ73944.1 | HMPREF3198_01821 | HMPREF3198_01101 | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | KEGG: lmt:LMRG_02596 1.8e-280 anaerobic ribonucleoside-triphosphate reductase; K00527 ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 7.50. | 0.908 |
| KWZ72465.1 | dcd | HMPREF3198_01821 | HMPREF3198_00241 | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.927 |
| KWZ72465.1 | guaA | HMPREF3198_01821 | HMPREF3198_01611 | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.641 |
| KWZ72465.1 | thyA | HMPREF3198_01821 | HMPREF3198_00622 | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.446 |
| KWZ73944.1 | KWZ72465.1 | HMPREF3198_01101 | HMPREF3198_01821 | KEGG: lmt:LMRG_02596 1.8e-280 anaerobic ribonucleoside-triphosphate reductase; K00527 ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | 0.908 |
| KWZ73944.1 | dcd | HMPREF3198_01101 | HMPREF3198_00241 | KEGG: lmt:LMRG_02596 1.8e-280 anaerobic ribonucleoside-triphosphate reductase; K00527 ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 7.50. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.901 |
| KWZ75162.1 | KWZ75165.1 | HMPREF3198_00240 | HMPREF3198_00243 | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00. | 0.503 |
| KWZ75162.1 | dcd | HMPREF3198_00240 | HMPREF3198_00241 | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.822 |
| KWZ75162.1 | hrpB | HMPREF3198_00240 | HMPREF3198_00242 | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | KEGG: ach:Achl_1784 3.7e-186 ATP-dependent helicase HrpB; K03579 ATP-dependent helicase HrpB; Psort location: Cytoplasmic, score: 7.50. | 0.689 |
| KWZ75165.1 | KWZ75162.1 | HMPREF3198_00243 | HMPREF3198_00240 | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.503 |
| KWZ75165.1 | dcd | HMPREF3198_00243 | HMPREF3198_00241 | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00. | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.503 |
| KWZ75165.1 | hrpB | HMPREF3198_00243 | HMPREF3198_00242 | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00. | KEGG: ach:Achl_1784 3.7e-186 ATP-dependent helicase HrpB; K03579 ATP-dependent helicase HrpB; Psort location: Cytoplasmic, score: 7.50. | 0.559 |
| dcd | KWZ72465.1 | HMPREF3198_00241 | HMPREF3198_01821 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | KEGG: cga:Celgi_2121 4.3e-41 Nucleoside-diphosphate kinase; K00940 nucleoside-diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. | 0.927 |
| dcd | KWZ73944.1 | HMPREF3198_00241 | HMPREF3198_01101 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | KEGG: lmt:LMRG_02596 1.8e-280 anaerobic ribonucleoside-triphosphate reductase; K00527 ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 7.50. | 0.901 |
| dcd | KWZ75162.1 | HMPREF3198_00241 | HMPREF3198_00240 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.822 |
| dcd | KWZ75165.1 | HMPREF3198_00241 | HMPREF3198_00243 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00. | 0.503 |
| dcd | guaA | HMPREF3198_00241 | HMPREF3198_01611 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.483 |
| dcd | hrpB | HMPREF3198_00241 | HMPREF3198_00242 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | KEGG: ach:Achl_1784 3.7e-186 ATP-dependent helicase HrpB; K03579 ATP-dependent helicase HrpB; Psort location: Cytoplasmic, score: 7.50. | 0.689 |
| dcd | nucS | HMPREF3198_00241 | HMPREF3198_01346 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. | 0.435 |
| dcd | thyA | HMPREF3198_00241 | HMPREF3198_00622 | dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.834 |