| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ74538.1 | folD | HMPREF3198_00713 | HMPREF3198_01473 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.801 |
| KWZ74538.1 | purC | HMPREF3198_00713 | HMPREF3198_00283 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | KEGG: xce:Xcel_3133 1.1e-99 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 7.50; Belongs to the SAICAR synthetase family. | 0.997 |
| KWZ74538.1 | purD | HMPREF3198_00713 | HMPREF3198_00288 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cfi:Celf_3231 1.6e-137 phosphoribosylamine/glycine ligase K01945; Psort location: Cytoplasmic, score: 7.50; Belongs to the GARS family. | 0.961 |
| KWZ74538.1 | purE | HMPREF3198_00713 | HMPREF3198_01438 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.917 |
| KWZ74538.1 | purF | HMPREF3198_00713 | HMPREF3198_01052 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.927 |
| KWZ74538.1 | purH | HMPREF3198_00713 | HMPREF3198_01625 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: mcu:HMPREF0573_10110 7.1e-199 purH; IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.996 |
| KWZ74538.1 | purL | HMPREF3198_00713 | HMPREF3198_00279 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.843 |
| KWZ74538.1 | purM | HMPREF3198_00713 | HMPREF3198_01053 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cfi:Celf_3180 9.2e-119 phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 9.97. | 0.864 |
| KWZ74538.1 | purN | HMPREF3198_00713 | HMPREF3198_01627 | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.932 |
| folD | KWZ74538.1 | HMPREF3198_01473 | HMPREF3198_00713 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | 0.801 |
| folD | purC | HMPREF3198_01473 | HMPREF3198_00283 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: xce:Xcel_3133 1.1e-99 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 7.50; Belongs to the SAICAR synthetase family. | 0.400 |
| folD | purD | HMPREF3198_01473 | HMPREF3198_00288 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: cfi:Celf_3231 1.6e-137 phosphoribosylamine/glycine ligase K01945; Psort location: Cytoplasmic, score: 7.50; Belongs to the GARS family. | 0.964 |
| folD | purE | HMPREF3198_01473 | HMPREF3198_01438 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.484 |
| folD | purF | HMPREF3198_01473 | HMPREF3198_01052 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.516 |
| folD | purH | HMPREF3198_01473 | HMPREF3198_01625 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: mcu:HMPREF0573_10110 7.1e-199 purH; IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.977 |
| folD | purL | HMPREF3198_01473 | HMPREF3198_00279 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.509 |
| folD | purM | HMPREF3198_01473 | HMPREF3198_01053 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: cfi:Celf_3180 9.2e-119 phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 9.97. | 0.569 |
| folD | purN | HMPREF3198_01473 | HMPREF3198_01627 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.980 |
| folD | purT | HMPREF3198_01473 | HMPREF3198_00146 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.913 |
| purC | KWZ74538.1 | HMPREF3198_00283 | HMPREF3198_00713 | KEGG: xce:Xcel_3133 1.1e-99 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 7.50; Belongs to the SAICAR synthetase family. | Putative adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | 0.997 |
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