| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ72059.1 | KWZ74792.1 | HMPREF3198_02157 | HMPREF3198_00429 | KEGG: xce:Xcel_1658 1.4e-44 CDP-alcohol phosphatidyltransferase; K00995 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 0.844 |
| KWZ72059.1 | KWZ74986.1 | HMPREF3198_02157 | HMPREF3198_00631 | KEGG: xce:Xcel_1658 1.4e-44 CDP-alcohol phosphatidyltransferase; K00995 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phospholipase D domain protein; KEGG: mcu:HMPREF0573_10007 4.2e-114 cls; cardiolipin synthetase K06131; Psort location: CytoplasmicMembrane, score: 8.78. | 0.517 |
| KWZ72059.1 | pgsA | HMPREF3198_02157 | HMPREF3198_01872 | KEGG: xce:Xcel_1658 1.4e-44 CDP-alcohol phosphatidyltransferase; K00995 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | KEGG: mcu:HMPREF0573_11419 2.0e-36 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase K00995; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.957 |
| KWZ72458.1 | KWZ73267.1 | HMPREF3198_01814 | HMPREF3198_01626 | Threonine synthase; KEGG: cpk:Cp1002_1475 1.9e-150 thrC; Threonine synthase; K01733 threonine synthase; Psort location: Cytoplasmic, score: 7.50. | 4-phosphoerythronate dehydrogenase; KEGG: gth:Geoth_3483 2.2e-44 Glyoxylate reductase (NADP(+)); Psort location: CytoplasmicMembrane, score: 8.16. | 0.558 |
| KWZ72458.1 | KWZ74792.1 | HMPREF3198_01814 | HMPREF3198_00429 | Threonine synthase; KEGG: cpk:Cp1002_1475 1.9e-150 thrC; Threonine synthase; K01733 threonine synthase; Psort location: Cytoplasmic, score: 7.50. | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 0.586 |
| KWZ72561.1 | KWZ74792.1 | HMPREF3198_01919 | HMPREF3198_00429 | KEGG: cfl:Cfla_1616 2.6e-27 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 7.50. | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 0.702 |
| KWZ72561.1 | hisA | HMPREF3198_01919 | HMPREF3198_01920 | KEGG: cfl:Cfla_1616 2.6e-27 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 7.50. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: bad:BAD_1124 6.0e-67 hisA; phosphoribosyl isomerase A K01814; Psort location: Cytoplasmic, score: 9.67. | 0.999 |
| KWZ72561.1 | hisC | HMPREF3198_01919 | HMPREF3198_01240 | KEGG: cfl:Cfla_1616 2.6e-27 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 7.50. | Histidinol-phosphate transaminase; KEGG: ksk:KSE_40050 1.1e-72 pat; putative phenylalanine aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: CytoplasmicMembrane, score: 8.16; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.920 |
| KWZ73267.1 | KWZ72458.1 | HMPREF3198_01626 | HMPREF3198_01814 | 4-phosphoerythronate dehydrogenase; KEGG: gth:Geoth_3483 2.2e-44 Glyoxylate reductase (NADP(+)); Psort location: CytoplasmicMembrane, score: 8.16. | Threonine synthase; KEGG: cpk:Cp1002_1475 1.9e-150 thrC; Threonine synthase; K01733 threonine synthase; Psort location: Cytoplasmic, score: 7.50. | 0.558 |
| KWZ73267.1 | KWZ74792.1 | HMPREF3198_01626 | HMPREF3198_00429 | 4-phosphoerythronate dehydrogenase; KEGG: gth:Geoth_3483 2.2e-44 Glyoxylate reductase (NADP(+)); Psort location: CytoplasmicMembrane, score: 8.16. | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 0.763 |
| KWZ73267.1 | glyA | HMPREF3198_01626 | HMPREF3198_01474 | 4-phosphoerythronate dehydrogenase; KEGG: gth:Geoth_3483 2.2e-44 Glyoxylate reductase (NADP(+)); Psort location: CytoplasmicMembrane, score: 8.16. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.473 |
| KWZ74792.1 | KWZ72059.1 | HMPREF3198_00429 | HMPREF3198_02157 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: xce:Xcel_1658 1.4e-44 CDP-alcohol phosphatidyltransferase; K00995 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.844 |
| KWZ74792.1 | KWZ72458.1 | HMPREF3198_00429 | HMPREF3198_01814 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | Threonine synthase; KEGG: cpk:Cp1002_1475 1.9e-150 thrC; Threonine synthase; K01733 threonine synthase; Psort location: Cytoplasmic, score: 7.50. | 0.586 |
| KWZ74792.1 | KWZ72561.1 | HMPREF3198_00429 | HMPREF3198_01919 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cfl:Cfla_1616 2.6e-27 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 7.50. | 0.702 |
| KWZ74792.1 | KWZ73267.1 | HMPREF3198_00429 | HMPREF3198_01626 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 4-phosphoerythronate dehydrogenase; KEGG: gth:Geoth_3483 2.2e-44 Glyoxylate reductase (NADP(+)); Psort location: CytoplasmicMembrane, score: 8.16. | 0.763 |
| KWZ74792.1 | KWZ74793.1 | HMPREF3198_00429 | HMPREF3198_00430 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: mcu:HMPREF0573_10554 1.3e-55 gpmB; phosphoglycerate mutase; Psort location: Cytoplasmic, score: 7.50. | 0.692 |
| KWZ74792.1 | KWZ74986.1 | HMPREF3198_00429 | HMPREF3198_00631 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | Phospholipase D domain protein; KEGG: mcu:HMPREF0573_10007 4.2e-114 cls; cardiolipin synthetase K06131; Psort location: CytoplasmicMembrane, score: 8.78. | 0.817 |
| KWZ74792.1 | glyA | HMPREF3198_00429 | HMPREF3198_01474 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.620 |
| KWZ74792.1 | hisA | HMPREF3198_00429 | HMPREF3198_01920 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: bad:BAD_1124 6.0e-67 hisA; phosphoribosyl isomerase A K01814; Psort location: Cytoplasmic, score: 9.67. | 0.699 |
| KWZ74792.1 | hisC | HMPREF3198_00429 | HMPREF3198_01240 | HAD hydrolase, family IB; KEGG: crd:CRES_1952 2.3e-42 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50. | Histidinol-phosphate transaminase; KEGG: ksk:KSE_40050 1.1e-72 pat; putative phenylalanine aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: CytoplasmicMembrane, score: 8.16; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.579 |