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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (583 aa)    
Predicted Functional Partners:
KWZ74807.1
KEGG: bcv:Bcav_3233 1.8e-67 isochorismate synthase; K02552 menaquinone-specific isochorismate synthase; Psort location: Cytoplasmic, score: 9.97.
 
 0.994
menC
Mandelate racemase/muconate lactonizing enzyme protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
  
 0.983
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
  
 0.981
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.907
KWZ74800.1
O-succinylbenzoate-CoA ligase family protein; KEGG: cfi:Celf_0920 4.4e-64 AMP-dependent synthetase and ligase; K01911 O-succinylbenzoic acid--CoA ligase; Psort location: Cytoplasmic, score: 7.50.
 
   
 0.856
menG
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.800
KWZ74803.1
Hypothetical protein; KEGG: cjk:jk1044 0.0073 5'-nucleotidase; K01081 5'-nucleotidase; Psort location: CytoplasmicMembrane, score: 9.55.
       0.773
KWZ72175.1
Hypothetical protein.
 
   
 0.633
KWZ74806.1
Trypsin; KEGG: bcv:Bcav_3234 1.7e-92 2-alkenal reductase; K08372 putative serine protease PepD.
       0.605
KWZ74205.1
Hydrolase, alpha/beta domain protein; KEGG: mbo:Mb3694 1.7e-39 ephE; epoxide hydrolase; Psort location: Cytoplasmic, score: 7.94.
  
 
 0.442
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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