STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KWZ74982.1ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: mcu:HMPREF0573_10012 4.2e-107 histidine kinase; Psort location: Cytoplasmic, score: 7.50. (487 aa)    
Predicted Functional Partners:
KWZ72176.1
Response regulator receiver domain protein; KEGG: bde:BDP_0990 7.8e-42 two-component system response regulator K07183; Psort location: Cytoplasmic, score: 9.97.
 
   
 0.857
KWZ74981.1
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.625
KWZ74979.1
OsmC-like protein; Psort location: Cytoplasmic, score: 7.50.
 
     0.606
whiB
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.590
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.580
KWZ74976.1
Dihydrofolate reductase; KEGG: mcu:HMPREF0573_10015 5.3e-36 putative dihydrofolate reductase; K00287 dihydrofolate reductase.
       0.572
KWZ74978.1
Signal peptide protein, YSIRK family; Psort location: CytoplasmicMembrane, score: 9.55.
       0.556
KWZ74980.1
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.556
KWZ74931.1
Hypothetical protein.
  
     0.528
whiB-3
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.493
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.