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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (347 aa)    
Predicted Functional Partners:
KWZ74183.1
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.995
hemA
glutamyl-tRNAGlu reductase domain protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.993
KWZ74182.1
KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89.
  
 0.990
KWZ74178.1
Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family.
 
 
 0.988
KWZ74180.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.981
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: pad:TIIST44_06205 5.2e-148 glutamate-1-semialdehyde 2,1-aminomutase; K01845 glutamate-1-semialdehyde 2,1-aminomutase; Psort location: Cytoplasmic, score: 9.67.
  
 0.951
KWZ72689.1
Putative glutamate-1-semialdehyde-2,1-aminomutase; KEGG: pfr:PFREUD_19260 2.6e-178 hemL2; glutamate-1-semialdehyde 2,1-aminomutase K01845; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.899
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.804
KWZ74179.1
Hypothetical protein; KEGG: swi:Swit_1248 3.1e-15 methylated-DNA--protein-cysteine methyltransferase K00567; Psort location: Cytoplasmic, score: 7.50.
       0.689
nadE
NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.666
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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