node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KWZ72877.1 | KWZ72945.1 | HMPREF3198_01229 | HMPREF3198_01299 | Hypothetical protein; KEGG: tra:Trad_1785 3.3e-27 NAD(P)H dehydrogenase (quinone); K00230 menaquinone-dependent protoporphyrinogen oxidase; Psort location: CytoplasmicMembrane, score: 9.55. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.853 |
KWZ72877.1 | KWZ74182.1 | HMPREF3198_01229 | HMPREF3198_00739 | Hypothetical protein; KEGG: tra:Trad_1785 3.3e-27 NAD(P)H dehydrogenase (quinone); K00230 menaquinone-dependent protoporphyrinogen oxidase; Psort location: CytoplasmicMembrane, score: 9.55. | KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89. | 0.918 |
KWZ72877.1 | hemH | HMPREF3198_01229 | HMPREF3198_00742 | Hypothetical protein; KEGG: tra:Trad_1785 3.3e-27 NAD(P)H dehydrogenase (quinone); K00230 menaquinone-dependent protoporphyrinogen oxidase; Psort location: CytoplasmicMembrane, score: 9.55. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.929 |
KWZ72945.1 | KWZ72877.1 | HMPREF3198_01299 | HMPREF3198_01229 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hypothetical protein; KEGG: tra:Trad_1785 3.3e-27 NAD(P)H dehydrogenase (quinone); K00230 menaquinone-dependent protoporphyrinogen oxidase; Psort location: CytoplasmicMembrane, score: 9.55. | 0.853 |
KWZ72945.1 | KWZ74182.1 | HMPREF3198_01299 | HMPREF3198_00739 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89. | 0.901 |
KWZ72945.1 | KWZ74183.1 | HMPREF3198_01299 | HMPREF3198_00740 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.879 |
KWZ72945.1 | hemC | HMPREF3198_01299 | HMPREF3198_00738 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.493 |
KWZ73037.1 | KWZ74182.1 | HMPREF3198_01395 | HMPREF3198_00739 | Phosphoribosyl transferase domain protein; KEGG: ccm:Ccan_18380 1.6e-05 protein COM101A; Psort location: Cytoplasmic, score: 7.50. | KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89. | 0.729 |
KWZ74178.1 | KWZ74180.1 | HMPREF3198_00735 | HMPREF3198_00737 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.959 |
KWZ74178.1 | KWZ74182.1 | HMPREF3198_00735 | HMPREF3198_00739 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89. | 0.779 |
KWZ74178.1 | KWZ74183.1 | HMPREF3198_00735 | HMPREF3198_00740 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.874 |
KWZ74178.1 | KWZ74186.1 | HMPREF3198_00735 | HMPREF3198_00743 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Chlorite O(2)-lyase; KEGG: pcn:TIB1ST10_01590 8.4e-61 ferrochelatase, HemH; K01772 ferrochelatase; Psort location: Cytoplasmic, score: 7.50. | 0.464 |
KWZ74178.1 | hemA | HMPREF3198_00735 | HMPREF3198_00741 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | glutamyl-tRNAGlu reductase domain protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.970 |
KWZ74178.1 | hemC | HMPREF3198_00735 | HMPREF3198_00738 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
KWZ74178.1 | hemH | HMPREF3198_00735 | HMPREF3198_00742 | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.629 |
KWZ74180.1 | KWZ74178.1 | HMPREF3198_00737 | HMPREF3198_00735 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; KEGG: pad:TIIST44_06210 2.9e-122 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | 0.959 |
KWZ74180.1 | KWZ74182.1 | HMPREF3198_00737 | HMPREF3198_00739 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | KEGG: cfl:Cfla_3436 1.1e-74 protoporphyrinogen oxidase K00231; Psort location: Cytoplasmic, score: 9.89. | 0.904 |
KWZ74180.1 | KWZ74183.1 | HMPREF3198_00737 | HMPREF3198_00740 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.985 |
KWZ74180.1 | KWZ74186.1 | HMPREF3198_00737 | HMPREF3198_00743 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Chlorite O(2)-lyase; KEGG: pcn:TIB1ST10_01590 8.4e-61 ferrochelatase, HemH; K01772 ferrochelatase; Psort location: Cytoplasmic, score: 7.50. | 0.537 |
KWZ74180.1 | hemA | HMPREF3198_00737 | HMPREF3198_00741 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNAGlu reductase domain protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.773 |