| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ72147.1 | KWZ73827.1 | HMPREF3198_02245 | HMPREF3198_01131 | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | Hypothetical protein. | 0.439 |
| KWZ72147.1 | KWZ74942.1 | HMPREF3198_02245 | HMPREF3198_00586 | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | 0.903 |
| KWZ72147.1 | topA | HMPREF3198_02245 | HMPREF3198_00330 | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.407 |
| KWZ72634.1 | KWZ73827.1 | HMPREF3198_01993 | HMPREF3198_01131 | ScpA/B protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | Hypothetical protein. | 0.587 |
| KWZ73827.1 | KWZ72147.1 | HMPREF3198_01131 | HMPREF3198_02245 | Hypothetical protein. | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | 0.439 |
| KWZ73827.1 | KWZ72634.1 | HMPREF3198_01131 | HMPREF3198_01993 | Hypothetical protein. | ScpA/B protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.587 |
| KWZ73827.1 | KWZ74942.1 | HMPREF3198_01131 | HMPREF3198_00586 | Hypothetical protein. | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | 0.670 |
| KWZ73827.1 | gyrB | HMPREF3198_01131 | HMPREF3198_00685 | Hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.439 |
| KWZ73827.1 | topA | HMPREF3198_01131 | HMPREF3198_00330 | Hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.439 |
| KWZ74942.1 | KWZ72147.1 | HMPREF3198_00586 | HMPREF3198_02245 | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | 0.903 |
| KWZ74942.1 | KWZ73827.1 | HMPREF3198_00586 | HMPREF3198_01131 | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | Hypothetical protein. | 0.670 |
| KWZ74942.1 | gyrB | HMPREF3198_00586 | HMPREF3198_00685 | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.903 |
| KWZ74942.1 | topA | HMPREF3198_00586 | HMPREF3198_00330 | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.990 |
| gyrB | KWZ73827.1 | HMPREF3198_00685 | HMPREF3198_01131 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Hypothetical protein. | 0.439 |
| gyrB | KWZ74942.1 | HMPREF3198_00685 | HMPREF3198_00586 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | 0.903 |
| gyrB | topA | HMPREF3198_00685 | HMPREF3198_00330 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.490 |
| topA | KWZ72147.1 | HMPREF3198_00330 | HMPREF3198_02245 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | DNA gyrase, B subunit protein; KEGG: mcu:HMPREF0573_11792 4.1e-251 gyrB; DNA topoisomerase K02470; Psort location: Cytoplasmic, score: 9.67. | 0.407 |
| topA | KWZ73827.1 | HMPREF3198_00330 | HMPREF3198_01131 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | Hypothetical protein. | 0.439 |
| topA | KWZ74942.1 | HMPREF3198_00330 | HMPREF3198_00586 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | HRDC domain protein; KEGG: xce:Xcel_0786 8.9e-192 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | 0.990 |
| topA | gyrB | HMPREF3198_00330 | HMPREF3198_00685 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.490 |