| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ72937.1 | KWZ75314.1 | HMPREF3198_01291 | HMPREF3198_00204 | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | 0.451 |
| KWZ72937.1 | dnaJ | HMPREF3198_01291 | HMPREF3198_01292 | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | 0.895 |
| KWZ72937.1 | hrcA | HMPREF3198_01291 | HMPREF3198_01293 | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.940 |
| KWZ75313.1 | KWZ75314.1 | HMPREF3198_00203 | HMPREF3198_00204 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | 0.976 |
| KWZ75313.1 | dnaJ | HMPREF3198_00203 | HMPREF3198_01292 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | 0.893 |
| KWZ75313.1 | dnaK | HMPREF3198_00203 | HMPREF3198_00206 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.962 |
| KWZ75313.1 | groL | HMPREF3198_00203 | HMPREF3198_01514 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.633 |
| KWZ75313.1 | groS | HMPREF3198_00203 | HMPREF3198_01489 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.491 |
| KWZ75313.1 | grpE | HMPREF3198_00203 | HMPREF3198_00205 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.983 |
| KWZ75313.1 | hrcA | HMPREF3198_00203 | HMPREF3198_01293 | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.779 |
| KWZ75314.1 | KWZ72937.1 | HMPREF3198_00204 | HMPREF3198_01291 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.451 |
| KWZ75314.1 | KWZ75313.1 | HMPREF3198_00204 | HMPREF3198_00203 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Transcriptional regulator, MerR family; KEGG: vfi:VF_A0114 8.2e-06 methyltransferase K00599; Psort location: Cytoplasmic, score: 7.50. | 0.976 |
| KWZ75314.1 | dnaK | HMPREF3198_00204 | HMPREF3198_00206 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
| KWZ75314.1 | groL | HMPREF3198_00204 | HMPREF3198_01514 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.837 |
| KWZ75314.1 | groS | HMPREF3198_00204 | HMPREF3198_01489 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.685 |
| KWZ75314.1 | grpE | HMPREF3198_00204 | HMPREF3198_00205 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.991 |
| KWZ75314.1 | hrcA | HMPREF3198_00204 | HMPREF3198_01293 | DnaJ domain protein; KEGG: apb:SAR116_1614 1.8e-49 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.67. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.763 |
| argR | hrcA | HMPREF3198_01228 | HMPREF3198_01293 | Arginine repressor protein; Regulates arginine biosynthesis genes. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.736 |
| argR | lexA | HMPREF3198_01228 | HMPREF3198_01884 | Arginine repressor protein; Regulates arginine biosynthesis genes. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.778 |
| dnaJ | KWZ72937.1 | HMPREF3198_01292 | HMPREF3198_01291 | Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...] | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.895 |
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