| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ73113.1 | KWZ73114.1 | HMPREF3198_01471 | HMPREF3198_01472 | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | 0.773 |
| KWZ73113.1 | folD | HMPREF3198_01471 | HMPREF3198_01473 | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.744 |
| KWZ73113.1 | glyA | HMPREF3198_01471 | HMPREF3198_01474 | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.677 |
| KWZ73114.1 | KWZ73113.1 | HMPREF3198_01472 | HMPREF3198_01471 | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | 0.773 |
| KWZ73114.1 | folD | HMPREF3198_01472 | HMPREF3198_01473 | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.684 |
| KWZ73114.1 | glyA | HMPREF3198_01472 | HMPREF3198_01474 | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.597 |
| folD | KWZ73113.1 | HMPREF3198_01473 | HMPREF3198_01471 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | 0.744 |
| folD | KWZ73114.1 | HMPREF3198_01473 | HMPREF3198_01472 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | 0.684 |
| folD | glyA | HMPREF3198_01473 | HMPREF3198_01474 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| glyA | KWZ73113.1 | HMPREF3198_01474 | HMPREF3198_01471 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: jde:Jden_0698 6.2e-65 exodeoxyribonuclease III Xth; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97. | 0.677 |
| glyA | KWZ73114.1 | HMPREF3198_01474 | HMPREF3198_01472 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Basic membrane protein; KEGG: apb:SAR116_1606 6.6e-13 membrane lipoprotein K07335. | 0.597 |
| glyA | folD | HMPREF3198_01474 | HMPREF3198_01473 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |