| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ73012.1 | glyA | HMPREF3198_01370 | HMPREF3198_01474 | KEGG: mcu:HMPREF0573_11182 3.0e-49 ribose-5-phosphate isomerase B K01808; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.869 |
| KWZ74526.1 | glyA | HMPREF3198_00701 | HMPREF3198_01474 | Aminotransferase, class I/II; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
| KWZ74526.1 | lpdA | HMPREF3198_00701 | HMPREF3198_01694 | Aminotransferase, class I/II; Psort location: Cytoplasmic, score: 9.97. | Dihydrolipoyl dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.912 |
| KWZ74892.1 | cysE | HMPREF3198_00535 | HMPREF3198_01789 | KEGG: ach:Achl_0534 1.3e-149 L-serine dehydratase K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family. | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | 0.925 |
| KWZ74892.1 | glyA | HMPREF3198_00535 | HMPREF3198_01474 | KEGG: ach:Achl_0534 1.3e-149 L-serine dehydratase K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
| KWZ74892.1 | trpB | HMPREF3198_00535 | HMPREF3198_01671 | KEGG: ach:Achl_0534 1.3e-149 L-serine dehydratase K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| cysE | KWZ74892.1 | HMPREF3198_01789 | HMPREF3198_00535 | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | KEGG: ach:Achl_0534 1.3e-149 L-serine dehydratase K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.925 |
| cysE | glyA | HMPREF3198_01789 | HMPREF3198_01474 | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.865 |
| cysE | pepN | HMPREF3198_01789 | HMPREF3198_01786 | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Membrane alanyl aminopeptidase; KEGG: ske:Sked_24580 1.9e-228 aminopeptidase N; K01256 aminopeptidase N; Psort location: Cytoplasmic, score: 9.97. | 0.501 |
| cysE | trpB | HMPREF3198_01789 | HMPREF3198_01671 | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.800 |
| folD | glyA | HMPREF3198_01473 | HMPREF3198_01474 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| folD | lpdA | HMPREF3198_01473 | HMPREF3198_01694 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrolipoyl dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.925 |
| folD | purH | HMPREF3198_01473 | HMPREF3198_01625 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: mcu:HMPREF0573_10110 7.1e-199 purH; IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.962 |
| folD | thyA | HMPREF3198_01473 | HMPREF3198_00622 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.943 |
| glyA | KWZ73012.1 | HMPREF3198_01474 | HMPREF3198_01370 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: mcu:HMPREF0573_11182 3.0e-49 ribose-5-phosphate isomerase B K01808; Psort location: Cytoplasmic, score: 7.50. | 0.869 |
| glyA | KWZ74526.1 | HMPREF3198_01474 | HMPREF3198_00701 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminotransferase, class I/II; Psort location: Cytoplasmic, score: 9.97. | 0.903 |
| glyA | KWZ74892.1 | HMPREF3198_01474 | HMPREF3198_00535 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: ach:Achl_0534 1.3e-149 L-serine dehydratase K01752; Psort location: Cytoplasmic, score: 7.50; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.974 |
| glyA | cysE | HMPREF3198_01474 | HMPREF3198_01789 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: bcv:Bcav_2610 2.4e-56 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | 0.865 |
| glyA | folD | HMPREF3198_01474 | HMPREF3198_01473 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
| glyA | lpdA | HMPREF3198_01474 | HMPREF3198_01694 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoyl dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.927 |
