STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa)    
Predicted Functional Partners:
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 0.999
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.995
KWZ73872.1
KEGG: cga:Celgi_2368 1.9e-40 glutamine amidotransferase; K01951 GMP synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 7.50.
  
 
 0.985
pheT
phenylalanine--tRNA ligase, beta subunit; KEGG: mcu:HMPREF0573_10030 5.7e-245 pheT; phenylalanine--tRNA ligase K01890; Psort location: Cytoplasmic, score: 9.97; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
   
  
 0.984
purH
Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: mcu:HMPREF0573_10110 7.1e-199 purH; IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.984
KWZ73164.1
5'-nucleotidase protein; KEGG: ahe:Arch_0203 2.4e-111 LPXTG-motif cell wall anchor domain-containing protein; K01081 5'-nucleotidase; Psort location: Cellwall, score: 9.20; Belongs to the 5'-nucleotidase family.
    
 0.970
hpt
KEGG: tbi:Tbis_3448 1.3e-66 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.969
KWZ72793.1
Hydrolase, NUDIX family; KEGG: krh:KRH_05700 4.6e-53 mutT; putative NTP pyrophosphohydrolase MutT; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.965
KWZ74398.1
LPXTG-motif protein cell wall anchor domain protein; KEGG: crd:CRES_1125 6.8e-91 nucI; 5-nucleotidase; Psort location: Cellwall, score: 9.20; Belongs to the 5'-nucleotidase family.
    
 0.952
ribA
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
  
  
 0.951
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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