| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ74262.1 | KWZ74745.1 | HMPREF3198_00820 | HMPREF3198_00382 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | 0.859 |
| KWZ74262.1 | clpB | HMPREF3198_00820 | HMPREF3198_00198 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.859 |
| KWZ74262.1 | clpP-2 | HMPREF3198_00820 | HMPREF3198_01807 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.977 |
| KWZ74262.1 | clpX | HMPREF3198_00820 | HMPREF3198_01808 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.933 |
| KWZ74262.1 | dnaK | HMPREF3198_00820 | HMPREF3198_00206 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.646 |
| KWZ74262.1 | groL | HMPREF3198_00820 | HMPREF3198_01514 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.556 |
| KWZ74262.1 | groS | HMPREF3198_00820 | HMPREF3198_01489 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.703 |
| KWZ74262.1 | grpE | HMPREF3198_00820 | HMPREF3198_00205 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.587 |
| KWZ74262.1 | hrcA | HMPREF3198_00820 | HMPREF3198_01293 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.580 |
| KWZ74262.1 | tig | HMPREF3198_00820 | HMPREF3198_01805 | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.412 |
| KWZ74745.1 | KWZ74262.1 | HMPREF3198_00382 | HMPREF3198_00820 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | 0.859 |
| KWZ74745.1 | clpP-2 | HMPREF3198_00382 | HMPREF3198_01807 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.880 |
| KWZ74745.1 | clpX | HMPREF3198_00382 | HMPREF3198_01808 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.478 |
| KWZ74745.1 | dnaK | HMPREF3198_00382 | HMPREF3198_00206 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.981 |
| KWZ74745.1 | groL | HMPREF3198_00382 | HMPREF3198_01514 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.678 |
| KWZ74745.1 | groS | HMPREF3198_00382 | HMPREF3198_01489 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.720 |
| KWZ74745.1 | grpE | HMPREF3198_00382 | HMPREF3198_00205 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.860 |
| KWZ74745.1 | hrcA | HMPREF3198_00382 | HMPREF3198_01293 | Negative regulator of genetic competence ClpC/MecB; KEGG: mbb:BCG_3661c 0. clpC; putative ATP-dependent Clp protease ATP-binding subunit ClpC K03696; Psort location: Cytoplasmic, score: 9.97. | Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.655 |
| clpB | KWZ74262.1 | HMPREF3198_00198 | HMPREF3198_00820 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: cde:CDHC02_1648 7.6e-147 clpP; ATP-dependent protease, protease subunit; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the peptidase S14 family. | 0.859 |
| clpB | clpP-2 | HMPREF3198_00198 | HMPREF3198_01807 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.880 |
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