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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCsuccinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)    
Predicted Functional Partners:
kgd
KEGG: bcv:Bcav_1274 0. kgd; alpha-ketoglutarate decarboxylase; K00164 2-oxoglutarate dehydrogenase E1 component; Psort location: Cytoplasmic, score: 9.97.
 0.999
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
KWZ73094.1
Citrate (Si)-synthase; KEGG: mcu:HMPREF0573_10956 9.2e-158 gltA; type II citrate synthase K01647; Psort location: Cytoplasmic, score: 9.97.
  
 0.987
sdhA
KEGG: pfr:PFREUD_14310 1.4e-287 sdhA3; succinate dehydrogenase flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89.
 
 0.987
KWZ73134.1
KEGG: mcu:HMPREF0573_10281 6.5e-102 sdhB; succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240; Psort location: Cytoplasmic, score: 9.89.
  
 0.985
sucB
KEGG: ahe:Arch_0735 2.8e-149 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Psort location: Cytoplasmic, score: 9.97.
 
 0.948
KWZ73255.1
KEGG: xce:Xcel_0693 1.6e-107 phosphate acetyltransferase K13788; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.947
KWZ74955.1
KEGG: gva:HMPREF0424_1199 5.6e-135 carbamoyl-phosphate synthase L chain, ATP binding domain protein; K11263 acetyl-/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein; Psort location: Cytoplasmic, score: 7.50.
  
 0.943
KWZ72775.1
Biotin-requiring enzyme; KEGG: cva:CVAR_1123 3.2e-35 sucB; dihydrolipoamide acyltransferase K00658; Psort location: Cytoplasmic, score: 9.67.
  
 0.942
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
   
 0.928
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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