STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
KWZ73909.1
KEGG: bcv:Bcav_1417 6.9e-114 3-isopropylmalate dehydrogenase K00052; Psort location: Cytoplasmic, score: 9.97.
 0.997
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.944
KWZ75240.1
Thiamine pyrophosphate enzyme, TPP binding domain protein; KEGG: mlu:Mlut_02710 1.3e-192 pyruvate dehydrogenase (cytochrome) K00156; Psort location: CytoplasmicMembrane, score: 9.51; Belongs to the TPP enzyme family.
  
 
 0.901
ilvD
Dihydroxy-acid dehydratase; KEGG: mcu:HMPREF0573_11178 3.6e-243 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 7.50; Belongs to the IlvD/Edd family.
 
  
 0.883
KWZ73912.1
2-isopropylmalate synthase/homocitrate synthase family protein; KEGG: ske:Sked_10800 4.7e-147 2-isopropylmalate synthase; K01649 2-isopropylmalate synthase; Psort location: Cytoplasmic, score: 7.50; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.845
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 
 0.815
KWZ74763.1
Pyruvate, phosphate dikinase; KEGG: mcu:HMPREF0573_10425 0. ppdK; pyruvate phosphate dikinase K01006; Psort location: Cytoplasmic, score: 9.97; Belongs to the PEP-utilizing enzyme family.
    
  0.807
KWZ74990.1
NAD-dependent malic enzyme; KEGG: iva:Isova_1566 2.5e-155 malic protein NAD-binding protein; K00027 malate dehydrogenase (oxaloacetate-decarboxylating); Psort location: Cytoplasmic, score: 7.50.
  
 
  0.804
aceE
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.801
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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