node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KWZ72527.1 | lexA | HMPREF3198_01885 | HMPREF3198_01884 | LysM domain protein; KEGG: nth:Nther_0484 2.2e-06 cell wall hydrolase SleB; K01449 N-acetylmuramoyl-L-alanine amidase; Psort location: CytoplasmicMembrane, score: 9.55. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.638 |
KWZ72527.1 | nrdR | HMPREF3198_01885 | HMPREF3198_01886 | LysM domain protein; KEGG: nth:Nther_0484 2.2e-06 cell wall hydrolase SleB; K01449 N-acetylmuramoyl-L-alanine amidase; Psort location: CytoplasmicMembrane, score: 9.55. | Putative transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.613 |
KWZ75047.1 | KWZ75049.1 | HMPREF3198_00345 | HMPREF3198_00347 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | 0.999 |
KWZ75047.1 | nrdI | HMPREF3198_00345 | HMPREF3198_00346 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.997 |
KWZ75047.1 | nrdR | HMPREF3198_00345 | HMPREF3198_01886 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.637 |
KWZ75047.1 | polA | HMPREF3198_00345 | HMPREF3198_02272 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.736 |
KWZ75047.1 | ribA | HMPREF3198_00345 | HMPREF3198_01295 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.937 |
KWZ75047.1 | ribD | HMPREF3198_00345 | HMPREF3198_01297 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.414 |
KWZ75049.1 | KWZ75047.1 | HMPREF3198_00347 | HMPREF3198_00345 | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
KWZ75049.1 | nadE | HMPREF3198_00347 | HMPREF3198_01623 | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.526 |
KWZ75049.1 | nrdI | HMPREF3198_00347 | HMPREF3198_00346 | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.992 |
KWZ75049.1 | nrdR | HMPREF3198_00347 | HMPREF3198_01886 | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | Putative transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.407 |
KWZ75049.1 | ribA | HMPREF3198_00347 | HMPREF3198_01295 | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.920 |
lexA | KWZ72527.1 | HMPREF3198_01884 | HMPREF3198_01885 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | LysM domain protein; KEGG: nth:Nther_0484 2.2e-06 cell wall hydrolase SleB; K01449 N-acetylmuramoyl-L-alanine amidase; Psort location: CytoplasmicMembrane, score: 9.55. | 0.638 |
lexA | nrdR | HMPREF3198_01884 | HMPREF3198_01886 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Putative transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.552 |
lexA | polA | HMPREF3198_01884 | HMPREF3198_02272 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.512 |
nadE | KWZ75049.1 | HMPREF3198_01623 | HMPREF3198_00347 | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Glutaredoxin; KEGG: apn:Asphe3_21430 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191. | 0.526 |
nadE | nrdR | HMPREF3198_01623 | HMPREF3198_01886 | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Putative transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.423 |
nadE | ribA | HMPREF3198_01623 | HMPREF3198_01295 | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.861 |
nadE | ribD | HMPREF3198_01623 | HMPREF3198_01297 | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.867 |