STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KWZ72616.1Putative methylated-DNA--[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (175 aa)    
Predicted Functional Partners:
KWZ73163.1
Toxin-antitoxin system, toxin component, GNAT family; KEGG: lbh:Lbuc_1321 1.7e-32 N-acetyltransferase GCN5; K03827 putative acetyltransferase; Psort location: CytoplasmicMembrane, score: 8.16.
      0.899
KWZ74179.1
Hypothetical protein; KEGG: swi:Swit_1248 3.1e-15 methylated-DNA--protein-cysteine methyltransferase K00567; Psort location: Cytoplasmic, score: 7.50.
  
     0.768
sigA
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
   0.600
KWZ72615.1
AMP-binding enzyme; KEGG: bcv:Bcav_2594 1.8e-147 AMP-dependent synthetase and ligase; K01897 long-chain acyl-CoA synthetase; Psort location: CytoplasmicMembrane, score: 8.78.
       0.542
pheT
phenylalanine--tRNA ligase, beta subunit; KEGG: mcu:HMPREF0573_10030 5.7e-245 pheT; phenylalanine--tRNA ligase K01890; Psort location: Cytoplasmic, score: 9.97; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.413
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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