| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KWZ72166.1 | carA | HMPREF3198_02264 | HMPREF3198_02199 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | 0.897 |
| KWZ72166.1 | carB | HMPREF3198_02264 | HMPREF3198_02200 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | KEGG: bcv:Bcav_2038 0. carbamoyl-phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.960 |
| KWZ72166.1 | purF | HMPREF3198_02264 | HMPREF3198_01052 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.447 |
| KWZ72166.1 | pyrB | HMPREF3198_02264 | HMPREF3198_02197 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | KEGG: mcu:HMPREF0573_11715 2.1e-121 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.960 |
| KWZ72166.1 | pyrC | HMPREF3198_02264 | HMPREF3198_02198 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.994 |
| KWZ72166.1 | pyrF | HMPREF3198_02264 | HMPREF3198_02201 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | KEGG: iva:Isova_1604 2.0e-68 Orotidine 5'-phosphate decarboxylase K01591; Psort location: Cytoplasmic, score: 7.50; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.959 |
| KWZ72166.1 | pyrR | HMPREF3198_02264 | HMPREF3198_02196 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Pyrimidine operon regulatory protein/uracil phosphoribosyltransferase PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.962 |
| argG | carA | HMPREF3198_01227 | HMPREF3198_02199 | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | 0.953 |
| argG | carB | HMPREF3198_01227 | HMPREF3198_02200 | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | KEGG: bcv:Bcav_2038 0. carbamoyl-phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.995 |
| argG | glmS | HMPREF3198_01227 | HMPREF3198_01500 | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Glutamine-fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.493 |
| argG | purF | HMPREF3198_01227 | HMPREF3198_01052 | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.548 |
| argG | pyrB | HMPREF3198_01227 | HMPREF3198_02197 | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | KEGG: mcu:HMPREF0573_11715 2.1e-121 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.954 |
| carA | KWZ72166.1 | HMPREF3198_02199 | HMPREF3198_02264 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.897 |
| carA | argG | HMPREF3198_02199 | HMPREF3198_01227 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | KEGG: cfi:Celf_1667 1.0e-181 argininosuccinate synthase K01940; Psort location: Cytoplasmic, score: 7.50; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.953 |
| carA | carB | HMPREF3198_02199 | HMPREF3198_02200 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | KEGG: bcv:Bcav_2038 0. carbamoyl-phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.999 |
| carA | glmS | HMPREF3198_02199 | HMPREF3198_01500 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | Glutamine-fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.920 |
| carA | purF | HMPREF3198_02199 | HMPREF3198_01052 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.959 |
| carA | purQ | HMPREF3198_02199 | HMPREF3198_00281 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.949 |
| carA | pyrB | HMPREF3198_02199 | HMPREF3198_02197 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | KEGG: mcu:HMPREF0573_11715 2.1e-121 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrC | HMPREF3198_02199 | HMPREF3198_02198 | KEGG: cga:Celgi_1781 6.0e-138 carbamoyl-phosphate synthase, small subunit; K01956 carbamoyl-phosphate synthase small subunit; Psort location: Cytoplasmic, score: 7.50; Belongs to the CarA family. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.998 |