STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
pfpPyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa)    
Predicted Functional Partners:
KWZ75300.1
Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
 
 
 0.936
KWZ72631.1
Transketolase; KEGG: mcu:HMPREF0573_11615 3.9e-237 tkt; transketolase K00615; Psort location: Cytoplasmic, score: 7.50; Belongs to the transketolase family.
  
 0.918
KWZ74772.1
Kinase, PfkB family; KEGG: mcu:HMPREF0573_11505 4.5e-94 putative fructokinase; K00847 fructokinase; Psort location: Cytoplasmic, score: 7.50.
   
  0.910
pfkA
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
  
 
0.905
manA
KEGG: cfi:Celf_2525 3.7e-99 mannose-6-phosphate isomerase, class I K01809; Psort location: Cytoplasmic, score: 7.50.
     
 0.903
pyk
Pyruvate kinase; KEGG: bcv:Bcav_2215 5.6e-183 pyruvate kinase K00873; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.770
KWZ72153.1
KEGG: mcu:HMPREF0573_11798 3.9e-159 aroH; 3-deoxy-7-phosphoheptulonate synthase K01626; Psort location: Cytoplasmic, score: 7.50; Belongs to the class-II DAHP synthase family.
       0.653
tpiA
Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
 0.626
pgi
KEGG: paz:TIA2EST2_10330 5.9e-211 pgi; glucose-6-phosphate isomerase K01810; Psort location: Cytoplasmic, score: 9.97; Belongs to the GPI family.
  
 
 0.617
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.616
Your Current Organism:
Winkia neuii
NCBI taxonomy Id: 33007
Other names: ATCC 51847, Actinomyces neuii, CCUG 32252, CIP 104015, DSM 8576, W. neuii, strain 97/90
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