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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (137 aa)    
Predicted Functional Partners:
parB
Chromosomal partitioning protein ParB; Function of strongly homologous gene; enzyme; Belongs to the ParB family.
      
 0.761
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
  
 0.739
cmk
Cytidylate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      0.735
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.720
ftsK
DNA translocase FtsK; Function of strongly homologous gene; enzyme.
     
 0.713
ssb
Single-stranded DNA-binding protein; Function of homologous gene experimentally demonstrated in an other organism; cell process.
      
 0.698
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.659
mazG
Nucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
      
 0.582
NIDE0165
Transcriptional regulator, LuxR family; Function of strongly homologous gene; regulator.
       0.549
NIDE0166
Putative Histidine kinase with N-terminal NAD-binding region; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
       0.549
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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