pepA protein (Nitrospira defluvii) - STRING interaction network

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pepA

Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (506 aa)

Predicted Functional Partners:

NIDE4085

0.983

nagZ

0.906

glyA

0.838

aspC

0.825

cysK

0.820

NIDE0322

0.628

nirK

0.627

czcA

0.623

czcA-2

0.623

czcA-3

0.623

Your Current Organism:

Nitrospira defluvii

NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NIDE0322	pepA	NIDE0322	NIDE0245	Homologs of previously reported genes of unknown function.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.628
NIDE4085	aspC	NIDE4085	NIDE2567	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Aspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.801
NIDE4085	cysK	NIDE4085	NIDE1821	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.815
NIDE4085	glyA	NIDE4085	NIDE0168	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.852
NIDE4085	pepA	NIDE4085	NIDE0245	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.983
aspC	NIDE4085	NIDE2567	NIDE4085	Aspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.801
aspC	cysK	NIDE2567	NIDE1821	Aspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.909
aspC	pepA	NIDE2567	NIDE0245	Aspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.825
cysK	NIDE4085	NIDE1821	NIDE4085	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.815
cysK	aspC	NIDE1821	NIDE2567	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Aspartate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.909
cysK	glyA	NIDE1821	NIDE0168	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.613
cysK	pepA	NIDE1821	NIDE0245	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.820
czcA	pepA	NIDE1765	NIDE0245	Cation efflux system protein CzcA; Function of strongly homologous gene; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.623
czcA-2	pepA	NIDE3251	NIDE0245	Heavy metal efflux pump, CzcA family; Function of strongly homologous gene; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.623
czcA-3	pepA	NIDE3755	NIDE0245	Cation efflux system protein CzcA; Function of strongly homologous gene; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.623
glyA	NIDE4085	NIDE0168	NIDE4085	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Putative Peptidase M; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.852
glyA	cysK	NIDE0168	NIDE1821	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.613
glyA	pepA	NIDE0168	NIDE0245	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.838
nagZ	pepA	NIDE0246	NIDE0245	Beta-N-acetylglucosaminidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.906
nirK	pepA	NIDE4252	NIDE0245	Copper-containing nitrite reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.627

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