Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
degPSerine protease Do; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (492 aa)    
Predicted Functional Partners:
hflC
FtsH protease activity modulator HflC; HflC and HflK could regulate a protease.
   
 
 0.764
rpoH
RNA polymerase, sigma 32 (sigma H) factor; Function of homologous gene experimentally demonstrated in an other organism; factor.
  
  
 0.762
hslV
Heat shock protein HslUV, peptidase component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
      
 0.760
fdsA
Formate dehydrogenase, alpha subunit; Function of strongly homologous gene; enzyme.
      
 0.756
rpoE
RNA polymerase sigma 24 (sigma E) factor; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.754
hflK
FtsH protease activity modulator HflK; HflC and HflK could encode or regulate a protease.
   
 
 0.741
clpP
ATP-dependent Clp protease, proteolytic subunit clpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
  
 0.652
pstB
Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
      
 0.632
cydA
Cytochrome bd oxidase, subunit I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
      
 0.622
cztR
Heavy metal response regulator; Function of strongly homologous gene; regulator.
  
    0.580
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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