| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE4164 | fhs | NIDE4164 | NIDE3713 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.938 |
| NIDE4164 | folD | NIDE4164 | NIDE0810 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
| NIDE4164 | gcvT | NIDE4164 | NIDE0320 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Aminomethyltransferase, glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.935 |
| NIDE4164 | glyA | NIDE4164 | NIDE0168 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
| NIDE4164 | metH | NIDE4164 | NIDE1868 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.948 |
| NIDE4164 | purH | NIDE4164 | NIDE2574 | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional purine biosynthesis protein PurH; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.910 |
| fhs | NIDE4164 | NIDE3713 | NIDE4164 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.938 |
| fhs | folD | NIDE3713 | NIDE0810 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
| fhs | gcvH | NIDE3713 | NIDE2728 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.402 |
| fhs | gcvP | NIDE3713 | NIDE0312 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Glycine dehydrogenase, glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.737 |
| fhs | gcvT | NIDE3713 | NIDE0320 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase, glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.935 |
| fhs | glyA | NIDE3713 | NIDE0168 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
| fhs | metH | NIDE3713 | NIDE1868 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
| fhs | purH | NIDE3713 | NIDE2574 | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.984 |
| folD | NIDE4164 | NIDE0810 | NIDE4164 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative Formimidoyltransferase-cyclodeaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.937 |
| folD | fhs | NIDE0810 | NIDE3713 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. | 0.998 |
| folD | gcvH | NIDE0810 | NIDE2728 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.739 |
| folD | gcvP | NIDE0810 | NIDE0312 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase, glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.884 |
| folD | gcvT | NIDE0810 | NIDE0320 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase, glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
| folD | glyA | NIDE0810 | NIDE0168 | Bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.981 |