Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
comESulfopyruvate decarboxylase, beta subunit; Function of strongly homologous gene; enzyme. (192 aa)    
Predicted Functional Partners:
comD
Sulfopyruvate decarboxylase, alpha subunit; Function of strongly homologous gene; enzyme.
  
  0.999
ilvH
Acetolactate synthase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.933
NIDE2903
Putative Phosphoenolpyruvate phosphomutase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.859
phnW
2-aminoethylphosphonate aminotransferase; Function of strongly homologous gene; enzyme.
 
 
 0.804
NIDE0735
Putative Sugar nucleotidyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
     0.785
NIDE0737
Homologs of previously reported genes of unknown function.
 
    0.737
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.734
NIDE3330
Conserved protein of unknown function, SDR family; Homologs of previously reported genes of unknown function; 7742302.
  
 0.643
ilvD
Dihydroxy-acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
  
 
 0.614
NIDE0736
Putative sugar nucleotidyltransferase and phosphatidyltransferase (bifunctional enzyme); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
     0.564
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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