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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pilRTranscriptional regulatory protein pilR; Function of strongly homologous gene; regulator. (459 aa)    
Predicted Functional Partners:
NIDE0778
Putative Sensor protein PilS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  0.992
rpoN
RNA polymerase, sigma-54 (sigma N) factor; Function of homologous gene experimentally demonstrated in an other organism; factor.
 
  
 0.946
ispE
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
       0.779
pilA2
Type IV pilin PilA; Function of homologous gene experimentally demonstrated in an other organism; structure.
      
 0.742
pstS
Phosphate ABC transporter, periplasmic phosphate-binding protein; Function of homologous gene experimentally demonstrated in an other organism; transporter.
      
 0.695
pilC
Type IV pilus biogenesis protein PilC; Function of strongly homologous gene; transporter.
       0.644
NIDE4272
Putative Sensor histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
   0.563
NIDE2283
Putative Sensor histidine kinase FleS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
   0.522
NIDE1119
Putative Histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 
   0.513
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
      
 0.499
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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