Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
apaHBis(5'-nucleosyl)-tetraphosphatase, symmetrical; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (272 aa)    
Predicted Functional Partners:
NIDE0813
Protein of unknown function, DUF309; No homology to any previously reported sequences.
       0.783
NIDE0308
Protein of unknown function, contains Ankyrin and Tetratricopeptide repeats; No homology to any previously reported sequences; 14659697, 7667876, 8108379, 9482716.
   
 
 0.729
NIDE0815
Putative Hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.723
yahD
Conserved protein of unknown function, contains Ankyrin repeats; Homologs of previously reported genes of unknown function; 15063798, 8108379.
    
 
 0.706
NIDE3602
Exported protein of unknown function, contains Ankyrin repeats; No homology to any previously reported sequences; 8108379.
    
 
 0.706
NIDE0816
Putative Hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.598
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.445
NIDE0817
Homologs of previously reported genes of unknown function.
       0.403
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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