Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ccsACytochrome c biogenesis protein CcsA (ResC-like); Function of strongly homologous gene; transporter. (304 aa)    
Predicted Functional Partners:
NIDE0847
Putative Cytochrome c biogenesis protein, ResB-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.985
ccdA
Cytochrome c biogenesis protein CcdA; Function of strongly homologous gene; enzyme.
 
  
 0.933
cobA/hemD
Uroporphyrinogen-III C-methyltransferase and Uroporphyrinogen-III synthase (modular protein); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family.
  
  
 0.859
hemD
Porphyrin biosynthesis protein HemD; Function of strongly homologous gene; enzyme.
  
  
 0.859
resA-2
Thiol-disulfide oxidoreductase ResA; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.836
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
      
 0.799
nuoCD
NADH-quinone oxidoreductase, subunits C and D; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
  
 0.751
resA2
Thiol-disulfide oxidoreductase ResA; Function of strongly homologous gene; enzyme.
  
  
 0.709
qcrB
Quinol-cytochrome c reductase, fused cytochrome b/c subunit; Function of strongly homologous gene; carrier.
  
  
 0.648
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.646
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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