| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIDE0862 | shc | NIDE0862 | NIDE0861 | Putative Adenosylhomocysteine nucleosidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Squalene-hopene cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.863 |
| NIDE0862 | smc | NIDE0862 | NIDE0860 | Putative Adenosylhomocysteine nucleosidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.459 |
| ftsY | smc | NIDE4087 | NIDE0860 | Cell division protein ftsY homolog; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.437 |
| gyrB | smc | NIDE0003 | NIDE0860 | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.459 |
| ispH | shc | NIDE0859 | NIDE0861 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Squalene-hopene cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.476 |
| ispH | smc | NIDE0859 | NIDE0860 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.483 |
| scpA | scpB | NIDE1417 | NIDE1418 | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | Segregation and condensation protein B (modular protein); Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | 0.999 |
| scpA | smc | NIDE1417 | NIDE0860 | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.960 |
| scpB | scpA | NIDE1418 | NIDE1417 | Segregation and condensation protein B (modular protein); Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.999 |
| scpB | smc | NIDE1418 | NIDE0860 | Segregation and condensation protein B (modular protein); Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.819 |
| scpB | topA | NIDE1418 | NIDE1020 | Segregation and condensation protein B (modular protein); Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.767 |
| shc | NIDE0862 | NIDE0861 | NIDE0862 | Squalene-hopene cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative Adenosylhomocysteine nucleosidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.863 |
| shc | ispH | NIDE0861 | NIDE0859 | Squalene-hopene cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.476 |
| shc | smc | NIDE0861 | NIDE0860 | Squalene-hopene cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.473 |
| smc | NIDE0862 | NIDE0860 | NIDE0862 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | Putative Adenosylhomocysteine nucleosidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.459 |
| smc | ftsY | NIDE0860 | NIDE4087 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | Cell division protein ftsY homolog; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.437 |
| smc | gyrB | NIDE0860 | NIDE0003 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.459 |
| smc | ispH | NIDE0860 | NIDE0859 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.483 |
| smc | scpA | NIDE0860 | NIDE1417 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.960 |
| smc | scpB | NIDE0860 | NIDE1418 | Putative Chromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | Segregation and condensation protein B (modular protein); Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | 0.819 |