close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE0947Putative transmembrane signal transduction receptor and sigma-54 dependent response regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (901 aa)    
Predicted Functional Partners:
NIDE0405
Protein of unknown function, putative transcriptional regulator; No homology to any previously reported sequences; 11183780, 11532124, 1619650, 1986310, 9738943.
     
 0.908
rpoN
RNA polymerase, sigma-54 (sigma N) factor; Function of homologous gene experimentally demonstrated in an other organism; factor.
 
   
 0.779
NIDE2654
Chemosensory pili system protein ChpA (sensor histidine kinase/response regulator); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.599
NIDE0805
Putative Hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.583
NIDE0815
Putative Hybrid histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.583
NIDE0542
Protein of unknown function, putative Histidine kinase; No homology to any previously reported sequences.
   
 
 0.525
NIDE3570
Putative Hybrid sensor histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 
 0.524
NIDE0946
Conserved protein of unknown function, putative SAM-dependent methyltransferase; Homologs of previously reported genes of unknown function; 2541254, 3248728, 7607512, 7663118, 7971991; Belongs to the methyltransferase superfamily.
       0.518
NIDE1772
Putative Sensor histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.512
NIDE0948
Protein of unknown function, TPR-like; No homology to any previously reported sequences; 11777911, 14659697, 15223324, 1882418, 7667876, 9482716.
   
   0.507
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.