Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hinTPurine nucleoside phosphoramidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (114 aa)    
Predicted Functional Partners:
hisI
Fused Phosphoribosyl-AMP cyclohydrolase and Phosphoribosyl-ATP diphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family.
  
    0.821
glnA
Glutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
   0.736
hisF
Imidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
       0.726
tly
Hemolysin TlyA-family protein; Function of strongly homologous gene; factor.
      0.699
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
       0.580
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
   
   0.569
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
    0.557
NIDE0984
Homologs of previously reported genes of unknown function.
       0.550
rpoD-2
RNA polymerase sigma factor RpoD (Sigma-70); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
       0.543
lysS
Lysyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 0.436
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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