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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smfProtein SMF, putative DNA protecting protein DprA; Function of strongly homologous gene; phenotype. (378 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.931
yifB
Putative ATP-dependent protease, Mg chelatase-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
 0.918
NIDE1089
Putative Phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 
 0.915
NIDE2734
Putative Competence protein ComEC/Rec2 related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.908
pilD
Type IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
  
  
 0.783
pyrB
Aspartate carbamoyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
      0.656
NIDE3068
Conserved protein of unknown function, UPF0102; Homologs of previously reported genes of unknown function; Belongs to the UPF0102 family.
 
    0.656
fliP
Flagellar biosynthetic protein FliP, export component; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family.
  
    0.654
rng
Ribonuclease G; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
    0.606
NIDE2290
Two-component system, NtrC family, nitrogen regulation response regulator NtrX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
  
    0.601
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.