Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
NIDE1059Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the GcvT family. (363 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase, glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.997
gcvH
Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.993
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.847
lpd
Dihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.787
NIDE4341
Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.746
NIDE1060
Protein of unknown function, putative CheY-like signal transduction response regulator; No homology to any previously reported sequences; 11359578, 14636076, 17050923, 1869568, 2645526, 2999789, 8257674.
       0.736
sthA-2
Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.688
NIDE1061
Conserved protein of unknown function, contains TPR repeats; Homologs of previously reported genes of unknown function.
       0.671
NIDE1146
Putative Mercuric reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
 0.584
sthA
Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.568
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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