Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (308 aa)    
Predicted Functional Partners:
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.994
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.987
NIDE0722
Putative FMN reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.986
carB
Carbamoyl-phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family.
 
 
 0.955
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.944
pyrB
Aspartate carbamoyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.942
carA
Carbamoyl-phosphate synthase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family.
 
  
 0.927
NIDE3112
Putative Orotate phosphoribosyltransferase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 0.922
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.840
mreB
Cell shape determining protein MreB; Function of homologous gene experimentally demonstrated in an other organism; structure.
   
  
 0.818
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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