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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trxBThioredoxin-disulfide reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (304 aa)    
Predicted Functional Partners:
trxA
Thioredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the thioredoxin family.
 
 0.987
NIDE4034
Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
  
 0.986
NIDE1875
Probable Peroxiredoxin; Function of strongly homologous gene; enzyme.
  
 
 0.929
trxA-2
Thioredoxin; Function of strongly homologous gene; carrier; Belongs to the thioredoxin family.
  
 
 0.857
trxC
Thioredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier.
  
 
 0.857
fdx
2Fe-2S ferredoxin; Function of strongly homologous gene; carrier.
   
 
 0.843
fdxB
2Fe-2S ferredoxin; Function of strongly homologous gene; carrier.
   
 
 0.843
dnaX
DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 
 0.778
grpE
Chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]
  
  
 0.765
NIDE1202
Putative Thiol peroxidase (modular protein); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.757
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.