close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NIDE1146Putative Mercuric reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (517 aa)    
Predicted Functional Partners:
NIDE1145
Conserved membrane protein of unknown function, DedA family; Homologs of previously reported genes of unknown function.
     0.988
NIDE4034
Putative Thioredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.
  
 0.934
pdhC
Dihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; Function of strongly homologous gene; enzyme.
 0.901
NIDE3115
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.886
NIDE3854
Putative Pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase (E2) component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.874
NIDE1147
Homologs of previously reported genes of unknown function.
 
     0.842
gcvH
Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
  
 0.801
NIDE3114
Putative 2-oxoisovalerate dehydrogenase, beta subunit (Transketolase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 0.799
pdhB
Pyruvate dehydrogenase E1 component, beta subunit (Transketolase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.773
pdhB-2
Dehydrogenase (E1) component of pyruvate dehydrogenase complex, beta subunit (Transketolase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.773
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.