Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pycAPyruvate carboxylase, subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (472 aa)    
Predicted Functional Partners:
pycB
Pyruvate carboxylase, subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.997
pccB
Propionyl-CoA carboxylase; Function of strongly homologous gene; enzyme.
 
 0.963
aclA
ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.945
maeA
Malate dehydrogenase (oxaloacetate-decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.943
pykF
Pyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family.
   
 0.942
pykA
Pyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family.
   
 0.942
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.938
maeA2
NAD-dependent malic enzyme; Function of strongly homologous gene; enzyme.
   
 0.932
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
 
 0.927
prpC
2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
 
 0.927
Your Current Organism:
Nitrospira defluvii
NCBI taxonomy Id: 330214
Other names: Candidatus Nitrospira defluvii, LMG 27402, LMG:27402, N. defluvii, NCIMB 14950, strain A17
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